Metalation of Alkylpyridazines. IV. Nucleophilic Reaction of Lithiated Methylpyridazines (Supplement)

Anions formed from a reaction of pyridazine l-oxides having methyl groups in their 6-positions with lithium diisopropylamide underwent alkylation, acylation, and addition of electrophilic reagents, whereas pyridazine 1-oxides devoid of 6-methyl groups, e.g., pyridazine 1-oxide, 3-methylpyridazine 1-...

Full description

Saved in:
Bibliographic Details
Published inYAKUGAKU ZASSHI Vol. 100; no. 7; pp. 774 - 778
Main Authors OHSAWA, AKIO, UEZU, TOMIO, IGETA, HIROSHI
Format Journal Article
LanguageJapanese
English
Published The Pharmaceutical Society of Japan 1980
Subjects
acylation
addition
alkylation
heteroaromatics
metalation of methylpyridazine 1-oxides
pyridazine N-oxides
pyridazines
Online AccessGet full text

Cover

More Information
Summary:Anions formed from a reaction of pyridazine l-oxides having methyl groups in their 6-positions with lithium diisopropylamide underwent alkylation, acylation, and addition of electrophilic reagents, whereas pyridazine 1-oxides devoid of 6-methyl groups, e.g., pyridazine 1-oxide, 3-methylpyridazine 1-oxide, and 5-methylpyridazine 1-oxide underwent decomposition of materials under comparable conditions.
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.100.7_774