The Effect of Hibernation on Lipid Metabolism in the Neocortex of the Long-Tailed Ground Squirrel Spermophilus undulatus

• Published in: Biophysics (Oxford) Vol. 66; no. 5; pp. 828 - 833
• Main Authors: Markevich, L. N., Bykova, O. V., Lakhina, A. A., Kolomiytseva, I. K.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.09.2021; Springer Nature B.V
• Subjects: Acetic acid; Biological and Medical Physics; Biophysics; Complex Systems Biophysics; Dormancy; Fatty acids; Hibernation; Lecithin; Lipid metabolism; Lipids; Neocortex; Phosphatidylcholine; Phosphatidylinositol; Phosphatidylserine; Phospholipid composition; Phospholipids; Physics; Physics and Astronomy; Rodents; Spermophilus undulatus; Torpor; lipids; neocortex; long-tailed ground squirrel; hibernation
• ISSN: 0006-3509; 1555-6654
• DOI: 10.1134/S0006350921050122

The effect of hibernation on the content of individual phospholipids and neutral lipids, as well as the effect of the states of torpor (dormant long-tailed ground squirrels Spermophilus undulatus ) and exit from it (winter active long-tailed ground squirrels) on the synthesis of lipids in the neocortex tissue have been shown. A decrease in the content of fatty acids and diglycerides in the neocortex of active long-tailed ground squirrels compared to summer animals was found. The incorporation of the label in the tissue and lipids of the neocortex in awakened long-tailed ground squirrels was reduced by 25%; this was explained by a decrease in the concentration of 14 C-acetate due to the utilization of acetate during respiration in awakened long-tailed ground squirrels. Lipids of the neocortex of the long-tailed ground squirrel participate in adaptation to hypobiosis by increasing the content of the total fraction of phospholipids and modifying the phospholipid composition with an increase in the proportions of phosphatidylcholine, phosphatidylinositol, and phosphatidylserine.