Bilateral tonic pupils secondary to anti-GD2 antibody therapy for neuroblastoma

We report the case of a 12-year-old girl with stage 4 neuroblastoma who developed tonic pupils secondary to immunotherapy with dinutuximab, an anti-GD2 antibody, based on the timeline provided by her mother with regard to onset of symptoms. The patient presented with difficulty reading and chronic d...

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Bibliographic Details
Published inJournal of AAPOS Vol. 28; no. 2; p. 103852
Main Authors Edwards, Christopher M., Elefant, Daniel, Isakoff, Michael S., Gaffar, Majida A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2024
Subjects
Child
Female
Humans
Immunotherapy
Neuroblastoma - drug therapy
Tonic Pupil
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Summary:We report the case of a 12-year-old girl with stage 4 neuroblastoma who developed tonic pupils secondary to immunotherapy with dinutuximab, an anti-GD2 antibody, based on the timeline provided by her mother with regard to onset of symptoms. The patient presented with difficulty reading and chronic dilated pupils bilaterally, according to her mother’s observations over 6 months prior to presentation. Testing with dilute pilocarpine supported our presumption of tonic pupils.
ISSN:1091-8531
1528-3933
DOI:10.1016/j.jaapos.2024.103852