Rapid intraoperative parathyroid hormone testing with surgical pathology correlations: The chemical frozen section

The classic surgical approach to patients undergoing parathyroidectomy for primary or secondary hyperparathyroidism has experienced a dramatic shift owing to preoperative localization of the affected glands and/or the use of rapid intraoperative parathyroid hormone (RI-PTH) assays, allowing for mini...

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Bibliographic Details
Published inAmerican journal of clinical pathology Vol. 122; no. 5; pp. 704 - 712
Main Author GUARDA, Luis A
Format Journal Article
LanguageEnglish
Published Chicago, IL American Society of Clinical Pathologists 01.11.2004
Subjects
Adult
Aged
Biological and medical sciences
Calcium - blood
Female
Frozen Sections
Humans
Hyperparathyroidism - blood
Hyperparathyroidism - surgery
Immunoassay
Investigative techniques, diagnostic techniques (general aspects)
Luminescent Measurements
Male
Medical sciences
Middle Aged
Minimally Invasive Surgical Procedures
Monitoring, Intraoperative - methods
Parathyroid Glands - pathology
Parathyroid Glands - surgery
Parathyroid Hormone - blood
Parathyroidectomy
Pathology, Surgical - methods
Pathology, Surgical - standards
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Parathormone
Chemical frozen section
Anatomic pathology
Correlation
Rapid technique
Treatment
Parathyroid hormone
Surgery
Intraoperative
Intraoperative parathyroid hormone testing
Medical screening
Section
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Summary:The classic surgical approach to patients undergoing parathyroidectomy for primary or secondary hyperparathyroidism has experienced a dramatic shift owing to preoperative localization of the affected glands and/or the use of rapid intraoperative parathyroid hormone (RI-PTH) assays, allowing for minimally invasive surgical excisions. Institutional experience with 141 patients who underwent parathyroidectomy aided by the use of RI-PTH is reviewed. The orientation provided by the intraoperative assay is essential in guiding the surgeon in these minimally invasive procedures, it helps reveal the cases of primary hyperparathyroidism with involvement of more than 1 gland, and it replaces the need for performing frozen sections, except for cases of secondary hyperparathyroidism.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-9173
1943-7722
DOI:10.1309/RU5LDXWR1QNQA5WY