Granulocyte-colony stimulating factor-producing esophageal carcinosarcoma: a case report

An 80-year-old man presented at our hospital with chest oppression and vomiting. An endoscopic examination revealed a tumor in the lower portion of the esophagus, and the patient was diagnosed as possibly having esophageal carcinosarcoma based on a histological examination of endoscopic biopsy speci...

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Bibliographic Details
Published inEsophagus : official journal of the Japan Esophageal Society Vol. 4; no. 3; pp. 117 - 120
Main Authors Maejima, Kentaro, Watanabe, Masanori, Komine, Osamu, Mizutani, Satoshi, Bou, Hideki, Tokunaga, Akira, Tajiri, Takashi
Format Journal Article
LanguageEnglish
Published Heidelberg Springer Nature B.V 01.09.2007
Subjects
Case reports
Endoscopy
Esophageal cancer
Esophagus
Granulocytes
Medical diagnosis
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Summary:An 80-year-old man presented at our hospital with chest oppression and vomiting. An endoscopic examination revealed a tumor in the lower portion of the esophagus, and the patient was diagnosed as possibly having esophageal carcinosarcoma based on a histological examination of endoscopic biopsy specimens. During the initial medical examination, the patient had a high leukocyte count and a high level of serum granulocyte-colony stimulating factor (G-CSF). Moreover, immunohistochemical examination revealed cells that were positive for antibodies against G-CSF. Therefore, we diagnosed the patient as possibly having a G-CSF-producing esophageal carcinosarcoma. The patient died of tumor 4 months after the initial diagnosis.
ISSN:1612-9059
1612-9067
DOI:10.1007/s10388-007-0113-0