Evaluation of the results of the patients who underwent plasmapheresis in the pediatric intensive care unit

• Published in: Turkish journal of medical sciences Vol. 54; no. 3; pp. 508 - 516
• Main Authors: Talay, Mehmet Nur, Orhan, Özhan, Kanğin, Murat, Turanli, Eşe Eda, Özbek, Mehmet Nuri
• Format: Journal Article
• Language: English
• Published: Turkey Scientific and Technological Research Council of Turkey (TUBITAK) 01.01.2024
• Subjects: Adolescent; Child; Child, Preschool; Female; Hemolytic-Uremic Syndrome - therapy; Humans; Infant; Intensive Care Units, Pediatric; Male; Plasmapheresis - methods; Retrospective Studies; Treatment Outcome; mortality; pediatric intensive care unit; multisystem inflammatory syndrome; Therapeutic plasma exchange
• ISSN: 1300-0144; 1303-6165; 1300-0144
• DOI: 10.55730/1300-0144.5817

Therapeutic plasma exchange (TPE) is an extracorporeal treatment method that removes large molecular weight substances from plasma. In our study, we aimed to retrospectively examine the indications and procedural methods of the patients who had undergone TPE, and the complications that occurred during the procedure. Forty-one patients who were monitored in thePICU of Gazi Yaşargil Training and Research Hospital and had indications for TPE between 2017 and 2021 were included in the study. Laboratory parameters were checked before and after the TPE procedure. In addition to these, patients' diagnosis, weight, type of procedure and type of device, where the procedure was performed, duration of the procedure, amount of blood and plasma processed, complications, number of procedures, and death during the procedure or independent of the procedure were evaluated. The median age was 93.0 (14.0-167.0) months. Hemolytic uremic syndrome (HUS) was the most common TPE indication with nine patients. The most common complication related to TPE was fever (11 patients), while no complication was observed in 18 patients.When laboratory results were evaluated according to American Society for Apheresis (ASFA) categories, a significant improvement was observed in the values of platelet, AST, ALT, LDH, urea, and creatinine in ASFA1 after TPE. No significant improvement was observed in ASFA2 (p > 0.05). In ASFA3, a significant improvement was observed in INR, AST, ALT, LDH, total bilirubin, creatinine, pH, and lactate values after TPE (p < 0.05). Five patients died from ASFA1, one from ASFA2, and three patients from ASFA3. Since significant adjustments are observed in clinical and laboratory values in sepsis-MOF, which is in the ASFA3 category, we believe that it should be evaluated in the ASFA2 or ASFA1 category in the early treatment of these diseases. In addition, we think that MIS-C cases, which have not been in any category according to ASFA, should be included in the ASFA2 or ASFA3 category, considering our TPE results.