Deciphering the Relationship between Salivary Cortisol Levels and Hypertension Using Enzyme-linked Immunosorbent Assay - An Observational Study

Abstract Background: Cortisol plays a major role in stress crises and is higher among patients with hypertension. Assessment of cortisol levels can serve as a predictor for the prevention of complications of hypertension. Aim: The study aimed to investigate the relationship between salivary cortisol...

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Published inJournal of Nature and Science of Medicine Vol. 7; no. 1; pp. 63 - 66
Main Authors Sathiyamoorthy, Mounika, Divya, Bose, Ramadoss, Ramya, Dineshkumar, Thayalan, Narayan, Madhu, Vasanthi, V., Rameshkumar, Annasamy, Rajkumar, Krishnan
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer - Medknow 2024
Medknow Publications and Media Pvt. Ltd
Edition2
Subjects
Analysis
Corticosteroids
Enzyme-linked immunosorbent assay
Health aspects
Hydrocortisone
Hypertension
Medical research
Medicine, Experimental
Original Article
Physiological aspects
Saliva
Salivary glands
secretions
India
United States
saliva
cortisol
pulse pressure
Complications
hypertension
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Summary:Abstract Background: Cortisol plays a major role in stress crises and is higher among patients with hypertension. Assessment of cortisol levels can serve as a predictor for the prevention of complications of hypertension. Aim: The study aimed to investigate the relationship between salivary cortisol levels and hypertension. Materials and Methods: Twenty hypertensive individuals (Group I) and 20 control subjects (Group II) participated in the study. Their blood pressure was measured, followed by the collection of morning and evening saliva samples. Salivary cortisol levels were estimated using an enzyme-linked immunosorbent assay kit. Unpaired Student's t-test and Pearson's correlation coefficient were done to statistically analyze the data using SPSS statistical analysis software. Results: Group I had mean morning cortisol levels that were higher (0.376-0.458 g/dL) than those in Group II (0.005-0.0001 g/dL). In Group I participants, there was a positive correlation between evening cortisol levels and pulse pressure (P = 0.05). Conclusion: In this study, we found high cortisol levels in patients with hypertension. Increased salivary cortisol levels could be an indicator of underlying cardiovascular complications.
ISSN:2589-627X
2589-6288
DOI:10.4103/jnsm.jnsm_169_23