Plasma polyamines during pregnancy and their relationships with maternal allergies and the immune response of the neonates

• Published in: Pediatric allergy and immunology Vol. 35; no. 6; pp. e14167 - n/a
• Main Authors: Gázquez, Antonio, García‐Serna, Azahara M., Hernández‐Caselles, Trinidad, Martín‐Orozco, Elena, Cantero‐Cano, Esther, Prieto‐Sánchez, María T., Molina‐Ruano, María D., Castillo‐Lacalle, Rafaela, Vioque, Jesús, Morales, Eva, García‐Marcos, Luís, Larqué, Elvira, Candel‐Torralba, M. E., Garcia‐Marcos, L., Gimenez‐Banon, M. J., Martinez‐Torres, A., Morales, E., Perez‐Fernandez, V., Sanchez‐Solis, M., Nieto, A., Prieto‐Sanchez, M. T., Sanchez‐Ferrer, M., Fernanez‐Palacios, L., Gomez‐Gomez, V. P., Martinez‐Gracia, C., Peso‐Echarri, P., Ros‐Berruezo, G., Santaella‐Pascual, M., Gazquez, A., Larque, E., Pastor‐Fajardo, M. T., Sanchez‐Campillo, M., Serrano‐Munuera, A., Zornoza‐Moreno, M., Jimenez‐Guerrero, P., Adomnei, E., Arense‐Gonzalo, J. J., Mendiola, J., Navarro‐Lafuente, F., Torres‐Cantero, A. M., Salvador‐Garcia, C., Segovia‐Hernandez, M., Yagüe‐Guirao, G., Valero‐Guillen, P. L., Aviles‐Plaza, F. V., Cabezas‐Herrera, J., Martinez‐Lopez, A., Martinez‐Villanueva, M., Noguera‐Velasco, J. A., Franco‐Garcia, A., Garcia‐Serna, A. M., Hernandez‐Caselles, T., Martin‐Orozco, E., Norte‐Munoz, M., Canovas, M., Cantero‐Cano, E., Diego, T., Pastor, J. M., Sola‐Martínez, R. A., Esteban‐Gil, A., Fernandez‐Breis, J. T., Alcantara, M. V., Hernandez, S., Lopez‐Soler, C.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.06.2024
• Subjects: Adult; Allergic diseases; Allergies; allergy; Blood cells; Blood levels; Conjunctivitis; Cord blood; cytokine; Cytokines; Cytokines - blood; Cytokines - metabolism; Female; Fetal Blood - immunology; Hay fever; Humans; Hypersensitivity - blood; Hypersensitivity - immunology; Immune response; Infant, Newborn; Lymphocytes T; Maternal & child health; Neonates; Phenotypes; Plasma; polyamine; Polyamines; Pregnancy; Pregnancy Complications - blood; Pregnancy Complications - immunology; Spermidine; Spermidine - blood; Spermine; Th2 Cells - immunology; Umbilical cord; Veins & arteries; Womens health; cytokine; polyamine; spermidine; allergy; spermine
• ISSN: 0905-6157; 1399-3038
• DOI: 10.1111/pai.14167

Background Some studies have reported that polyamine levels may influence immune system programming. The aim of this study was to evaluate the polyamine profile during gestation and its associations with maternal allergy and cytokine production in cord blood cells in response to different allergenic stimuli. Methods Polyamines were determined in plasma of pregnant women (24 weeks, N = 674) and in umbilical cord samples (N = 353 vein and N = 160 artery) from the Mediterranean NELA birth cohort. Immune cell populations were quantified, and the production of cytokines in response to different allergic and mitogenic stimuli was assessed in cord blood. Results Spermidine and spermine were the most prevalent polyamines in maternal, cord venous, and cord arterial plasma. Maternal allergies, especially allergic conjunctivitis, were associated with lower spermine in umbilical cord vein. Higher levels of polyamines were associated with higher lymphocyte number but lower Th2‐related cells in cord venous blood. Those subjects with higher levels of circulating polyamines in cord showed lower production of inflammatory cytokines, especially IFN‐α, and lower production of Th2‐related cytokines, mainly IL‐4 and IL‐5. The effects of polyamines on Th1‐related cytokines production were uncertain. Conclusions Spermidine and spermine are the predominant polyamines in plasma of pregnant women at mid‐pregnancy and also in umbilical cord. Maternal allergic diseases like allergic conjunctivitis are related to lower levels of polyamines in cord vein, which could influence the immune response of the newborn. Cord polyamine content is related to a decreased Th2 response and inflammatory cytokines production, which might be important to reduce an allergenic phenotype in the neonate.