Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate

Triterpenes are derived from squalene or oxidosqualene. However, a new class of triterpenes derived from hexaprenyl pyrophosphate has been recently discovered, formed by a new family of chimeric class I triterpene synthases. The cyclization mechanisms of triterpenes were elucidated by isotopic label...

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Bibliographic Details
Published inEngineering Microbiology Vol. 2; no. 3; p. 100035
Main Author Hu, Dan
Format Journal Article
LanguageEnglish
Published Elsevier 01.09.2022
Subjects
Biosynthesis
Cyclization mechanisms
Non-squalene triterpenes
Terpene cyclase
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Summary:Triterpenes are derived from squalene or oxidosqualene. However, a new class of triterpenes derived from hexaprenyl pyrophosphate has been recently discovered, formed by a new family of chimeric class I triterpene synthases. The cyclization mechanisms of triterpenes were elucidated by isotopic labeling and protein structural analyses, which helps understand the biosynthesis of triterpenes in nature.
ISSN:2667-3703
2667-3703
DOI:10.1016/j.engmic.2022.100035