Pediatric TAFRO syndrome: A multi‐institution case series illustrating clinical challenges and excellent outcomes

A rare lymphoproliferative disorder involving thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), renal dysfunction (R), and organomegaly (O), called TAFRO syndrome, was first reported in 2010. Considered a variant of idiopathic multicentric Castleman's disease, the recent di...

Full description

Saved in:
Bibliographic Details
Published inPediatric blood & cancer Vol. 71; no. 10; pp. e31234 - n/a
Main Authors Johnson, Amanda K., Goteti, Sasidhar, Devald, Bar, Mestnik, Shelby, Ghosh, Taumoha, Williams, Robin, Doughty, Elizabeth S., Linden, Michael A., Beckman, Amy, Williams, Todd, Richardson, Kelsey, Martinelli, Marie
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.10.2024
Subjects
Adolescent
anemia
Castleman Disease - diagnosis
Castleman Disease - pathology
Castleman Disease - therapy
Castleman's disease
Diagnosis
Edema - etiology
Edema - pathology
Female
fever
Fever - etiology
Fibrosis
Humans
Infant
Lymphocytes
lymphoproliferative disorders
Male
organomegaly (TAFRO) syndrome
Patients
Pediatrics
renal dysfunction
Renal function
reticulin fibrosis
Syndrome
Thrombocytopenia
Thrombocytopenia - diagnosis
Thrombocytopenia - pathology
Thrombocytopenia - therapy
lymphoproliferative disorders
organomegaly (TAFRO) syndrome
Castleman's disease
thrombocytopenia
fever
reticulin fibrosis
renal dysfunction
anemia
Online AccessGet full text

Cover

More Information
Summary:A rare lymphoproliferative disorder involving thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), renal dysfunction (R), and organomegaly (O), called TAFRO syndrome, was first reported in 2010. Considered a variant of idiopathic multicentric Castleman's disease, the recent discovery and rarity of this syndrome pose challenges to diagnosis and management. Herein, we review three pediatric cases, including an infant, that illustrate the heterogeneity of TAFRO syndrome. Despite differences in presentation and treatment responses, all patients experienced excellent outcomes. This multi‐institutional case series highlights the need to work toward earlier diagnosis and improved long‐term management recommendations for patients with TAFRO syndrome.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1545-5009
1545-5017
1545-5017
DOI:10.1002/pbc.31234