Lysogeny destabilizes computationally simulated microbiomes

• Published in: Ecology letters Vol. 27; no. 6; pp. e14464 - n/a
• Main Authors: Gilman, R. Tucker, Muldoon, Mark R., Megremis, Spyridon, Robertson, David L., Chanishvili, Nina, Papadopoulos, Nikolaos G.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2024
• Subjects: Anna Karenina Principle; Bacteria; Bacteria - virology; bacteriophage; Bacteriophages - physiology; Computer Simulation; Disturbances; diversity; Ecosystem stability; Lysogeny; microbiome; Microbiomes; Microbiota; Models, Biological; Phages; Populations; Predators; Stability; Anna Karenina Principle; lysogeny; diversity; bacteriophage; microbiome; stability
• ISSN: 1461-023X; 1461-0248; 1461-0248
• DOI: 10.1111/ele.14464

Microbiomes are ecosystems, and their stability can impact the health of their hosts. Theory predicts that predators influence ecosystem stability. Phages are key predators of bacteria in microbiomes, but phages are unusual predators because many have lysogenic life cycles. It has been hypothesized that lysogeny can destabilize microbiomes, but lysogeny has no direct analog in classical ecological theory, and no formal theory exists. We studied the stability of computationally simulated microbiomes with different numbers of temperate (lysogenic) and virulent (obligate lytic) phage species. Bacterial populations were more likely to fluctuate over time when there were more temperate phages species. After disturbances, bacterial populations returned to their pre‐disturbance densities more slowly when there were more temperate phage species, but cycles engendered by disturbances dampened more slowly when there were more virulent phage species. Our work offers the first formal theory linking lysogeny to microbiome stability. Predation by phages shapes bacterial communities in microbiomes, but no theory exists to predict how lysogeny affects bacterial community composition and dynamics. We used computational models to show that lysogenic phages can destabilize bacterial communities, with potential impacts on the health of microbiome hosts.