Synthesis and in vivo evaluation of a new PET radioligand for imaging the cannabinoid type-1 (CB1) receptors

Discussion: The adequate brain entry and distribution of [11C]1 in monkey brain and successful blockade of uptake or displacement of a major portion of this radioactivity are compelling evidence of the efficacy of [11C]1 for imaging brain CB1 receptors with PET. Conditions for chiral separation have...

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Bibliographic Details
Published inNEUROIMAGE Vol. 31; p. T50
Main Authors Donohue, Sean, Halldin, C., Finnema, S., Gulyas, B., Pike, V.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier Inc 2006
Elsevier Limited
Subjects
Chromatography
Medical imaging
Medicin och hälsovetenskap
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Summary:Discussion: The adequate brain entry and distribution of [11C]1 in monkey brain and successful blockade of uptake or displacement of a major portion of this radioactivity are compelling evidence of the efficacy of [11C]1 for imaging brain CB1 receptors with PET. Conditions for chiral separation have been worked out with high-performance liquid chromatography (HPLC).
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.04.041