An Efficient Copper-Catalyzed C(sp(2))-S Formation Starting from Aryl Iodides and Tetramethylthiuram Monosulfide (TMTM)

A new, efficient copper-catalyzed C(sp(2))-S formation of phenyl dithiocarbamates starting from aryl iodides and tetramethylthiuram monosulfide (TMTM) was developed. The target compounds, phenyl dithiocarbamates with active sites, were synthesized smoothly in good to excellent yields. The easy perfo...

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Bibliographic Details
Published inSynthesis (Stuttgart) Vol. 52; no. 20; pp. 3001 - 3006
Main Authors Wu, Yue-Xiao, Peng, Kang, Li, Jing-Hang, Dong, Zhi-Bing
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 16.10.2020
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ISOTHIOCYANATES
REAGENTS
ANTIFUNGAL ACTIVITY
THIOAMIDES
ARYLBORONIC ACIDS
ZINC
TETRAALKYLTHIURAM DISULFIDES
dithiocarbamates
S-ARYLATION
thiuram
CHEMISTRY
sulfur
aryl iodide
DERIVATIVES
bond formation
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Summary:A new, efficient copper-catalyzed C(sp(2))-S formation of phenyl dithiocarbamates starting from aryl iodides and tetramethylthiuram monosulfide (TMTM) was developed. The target compounds, phenyl dithiocarbamates with active sites, were synthesized smoothly in good to excellent yields. The easy performance, high yields, decent functional group compatibility, and cost-effective substrates make the protocol practical and attractive in C-S bond formation.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0040-1707899