Structural characterization of a novel polysaccharide from sweet corncob that inhibits glycosylase in STZ-induced diabetic rats Structural characterization of a novel polysaccharide

In the current study, we extracted a polysaccharide from sweet corncob and evaluated its hypoglycemic function. After collection in water, alcohol precipitation, and purification by DEAE-52 and Sephadex G-100 columns, we obtained a polysaccharide (SCP50) that was composed primarily of mannose and gl...

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Published in	Glycoconjugate journal Vol. 39; no. 3; pp. 413 - 427
Main Authors	Wang, Xin, Xiu, Weiye, Han, Ye, Xie, Jingnan, Zhang, Kai, Zhou, Kechi, Ma, Yongqiang
Format	Journal Article
Language	English
Published	New York Springer US 01.06.2022
Subjects	alpha-Glucosidases - chemistry Animals Biochemistry Biomedical and Life Sciences Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Hypoglycemic Agents - chemistry Life Sciences Original Article Pathology Polysaccharides - chemistry Rats Zea mays Inhibition of glycosylase Hypoglycemic effect Sweet corncob polysaccharides Structural characterization
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Abstract	In the current study, we extracted a polysaccharide from sweet corncob and evaluated its hypoglycemic function. After collection in water, alcohol precipitation, and purification by DEAE-52 and Sephadex G-100 columns, we obtained a polysaccharide (SCP50) that was composed primarily of mannose and glucose (9.73:190.27), with a molecular weight of 9280.33 Da. We demonstrated that SCP50 exhibited significant inhibition of α-glucosidase activity, with an IC50 of 4.866 mg/mL, K m of 1.297 × 10 −3 , and V max of 0.076 mol/L·min −1 in vitro . We also observed that SCP50 markedly attenuated disaccharidase (maltase, sucrase, and lactase) activity in a rat model of T2DM. We conclude that SCP50 exerts a hypoglycemic effect via inhibition of intestinal glycosylase. These results thus provide new insight into the hypoglycemic action underlying sweet corncob polysaccharide’s effects.
AbstractList	In the current study, we extracted a polysaccharide from sweet corncob and evaluated its hypoglycemic function. After collection in water, alcohol precipitation, and purification by DEAE-52 and Sephadex G-100 columns, we obtained a polysaccharide (SCP50) that was composed primarily of mannose and glucose (9.73:190.27), with a molecular weight of 9280.33 Da. We demonstrated that SCP50 exhibited significant inhibition of α-glucosidase activity, with an IC50 of 4.866 mg/mL, Km of 1.297 × 10-3, and Vmax of 0.076 mol/L·min-1 in vitro. We also observed that SCP50 markedly attenuated disaccharidase (maltase, sucrase, and lactase) activity in a rat model of T2DM. We conclude that SCP50 exerts a hypoglycemic effect via inhibition of intestinal glycosylase. These results thus provide new insight into the hypoglycemic action underlying sweet corncob polysaccharide's effects.In the current study, we extracted a polysaccharide from sweet corncob and evaluated its hypoglycemic function. After collection in water, alcohol precipitation, and purification by DEAE-52 and Sephadex G-100 columns, we obtained a polysaccharide (SCP50) that was composed primarily of mannose and glucose (9.73:190.27), with a molecular weight of 9280.33 Da. We demonstrated that SCP50 exhibited significant inhibition of α-glucosidase activity, with an IC50 of 4.866 mg/mL, Km of 1.297 × 10-3, and Vmax of 0.076 mol/L·min-1 in vitro. We also observed that SCP50 markedly attenuated disaccharidase (maltase, sucrase, and lactase) activity in a rat model of T2DM. We conclude that SCP50 exerts a hypoglycemic effect via inhibition of intestinal glycosylase. These results thus provide new insight into the hypoglycemic action underlying sweet corncob polysaccharide's effects. In the current study, we extracted a polysaccharide from sweet corncob and evaluated its hypoglycemic function. After collection in water, alcohol precipitation, and purification by DEAE-52 and Sephadex G-100 columns, we obtained a polysaccharide (SCP50) that was composed primarily of mannose and glucose (9.73:190.27), with a molecular weight of 9280.33 Da. We demonstrated that SCP50 exhibited significant inhibition of α-glucosidase activity, with an IC50 of 4.866 mg/mL, K m of 1.297 × 10 −3 , and V max of 0.076 mol/L·min −1 in vitro . We also observed that SCP50 markedly attenuated disaccharidase (maltase, sucrase, and lactase) activity in a rat model of T2DM. We conclude that SCP50 exerts a hypoglycemic effect via inhibition of intestinal glycosylase. These results thus provide new insight into the hypoglycemic action underlying sweet corncob polysaccharide’s effects. In the current study, we extracted a polysaccharide from sweet corncob and evaluated its hypoglycemic function. After collection in water, alcohol precipitation, and purification by DEAE-52 and Sephadex G-100 columns, we obtained a polysaccharide (SCP50) that was composed primarily of mannose and glucose (9.73:190.27), with a molecular weight of 9280.33 Da. We demonstrated that SCP50 exhibited significant inhibition of α-glucosidase activity, with an IC50 of 4.866 mg/mL, K of 1.297 × 10 , and V of 0.076 mol/L·min in vitro. We also observed that SCP50 markedly attenuated disaccharidase (maltase, sucrase, and lactase) activity in a rat model of T2DM. We conclude that SCP50 exerts a hypoglycemic effect via inhibition of intestinal glycosylase. These results thus provide new insight into the hypoglycemic action underlying sweet corncob polysaccharide's effects.
Author	Xie, Jingnan Wang, Xin Ma, Yongqiang Han, Ye Zhou, Kechi Zhang, Kai Xiu, Weiye
Author_xml	– sequence: 1 givenname: Xin surname: Wang fullname: Wang, Xin email: wangxinfood@163.com organization: Heilongjiang Provincial Key Laboratory of Cereal and Comprehensive Processing of Cereal Resources, School of Food Engineering, Harbin University of Commerce – sequence: 2 givenname: Weiye surname: Xiu fullname: Xiu, Weiye organization: Heilongjiang Provincial Key Laboratory of Cereal and Comprehensive Processing of Cereal Resources, School of Food Engineering, Harbin University of Commerce – sequence: 3 givenname: Ye surname: Han fullname: Han, Ye organization: Heilongjiang Provincial Key Laboratory of Cereal and Comprehensive Processing of Cereal Resources, School of Food Engineering, Harbin University of Commerce – sequence: 4 givenname: Jingnan surname: Xie fullname: Xie, Jingnan organization: Heilongjiang Provincial Key Laboratory of Cereal and Comprehensive Processing of Cereal Resources, School of Food Engineering, Harbin University of Commerce – sequence: 5 givenname: Kai surname: Zhang fullname: Zhang, Kai organization: School of Life Science and Technology, Harbin Institute of Technology – sequence: 6 givenname: Kechi surname: Zhou fullname: Zhou, Kechi organization: Keshan Branch of Heilongjiang Academy of Agricultural Sciences – sequence: 7 givenname: Yongqiang surname: Ma fullname: Ma, Yongqiang email: qyma126@163.com organization: Heilongjiang Provincial Key Laboratory of Cereal and Comprehensive Processing of Cereal Resources, School of Food Engineering, Harbin University of Commerce
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Cites_doi	10.1111/1750-3841.13554 10.1016/j.ijbiomac.2020.06.244 10.1016/j.carbpol.2017.08.063 10.1016/j.ijbiomac.2018.12.231 10.1016/j.cger.2020.04.002 10.1016/j.jff.2017.12.067 10.1186/s12906-017-1684-5 10.1371/journal.pone.0160488 10.1016/j.ejmech.2019.05.083 10.1002/fsn3.1123 10.1016/j.carbpol.2014.02.079 10.1016/j.foodhyd.2019.06.002 10.1007/s10719-019-09901-2 10.1016/j.foodchem.2020.128218 10.1016/j.molstruc.2020.128110 10.1016/j.ijbiomac.2020.06.267 10.1007/S10719-021-10009-9 10.1016/j.jff.2018.12.039 10.1080/13880209.2016.1211153 10.1016/j.foodchem.2021.129261 10.1515/chem-2019-0056 10.1016/j.carbpol.2019.03.099 10.1080/003655298750026778 10.1136/bmj.k1795 10.1016/j.ijbiomac.2020.03.192 10.1016/j.carbpol.2019.115586 10.1016/j.algal.2020.101883 10.1016/j.bgm.2015.08.001 10.1016/j.diabres.2018.02.023 10.1016/j.nbd.2019.104608 10.1016/j.biopha.2020.110182 10.1016/j.jff.2019.01.037 10.1016/j.foodhyd.2020.105824 10.1016/j.carbpol.2017.06.084 10.3390/molecules26061677 10.1016/j.ijbiomac.2018.05.192 10.1016/j.carbpol.2017.01.092 10.1080/10942912.2017.1297952 10.3390/molecules22122271 10.1016/j.fct.2019.110886 10.1016/j.carbpol.2016.04.106 10.1016/j.foodres.2018.12.043 10.1016/j.jff.2016.10.026 10.1016/j.ijbiomac.2019.11.170 10.1177/1934578X1801300220 10.1016/j.ijbiomac.2018.10.200 10.1002/cbdv.201800070 10.1080/13880209.2017.1345953 10.1016/j.ijbiomac.2018.12.251 10.1016/j.jff.2019.103593 10.1016/j.carbpol.2020.116659 10.1016/j.ijbiomac.2020.02.161 10.1016/j.bioorg.2020.103625 10.1021/acs.jafc.5b05610 10.1016/j.foodhyd.2020.105851 10.1016/j.jff.2019.03.026
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Keywords	Inhibition of glycosylase Hypoglycemic effect Sweet corncob polysaccharides Structural characterization
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References	Staub (CR21) 1965; 5 Li, Luo, Luo, Guo, Yang, Hu, Zhang, Zhu (CR15) 2019; 55 Huo, Li, Xia, Wang, Xie, Wang, Zhou, Fu (CR10) 2021; 38 Dou, Chen, Fu (CR34) 2019; 96 CR39 Neyrinck, Barbara, Bernard, Georges, Raphaël, Cani, Laure, Nathalie (CR50) 2016; 11 Song, Teng, Zhu (CR33) 2020 CR38 CR37 CR36 CR35 CR31 CR30 Chen, Zhang, Huo, Cao, Li, Liang, Li, Li (CR47) 2019; 215 Fu, Yang, Ma, Li, Li, Yang, Xu, Wang (CR48) 2020 CR2 Thant, Aminah, Kristanti, Ramadhan, Takaya (CR53) 2019; 17 CR4 CR3 CR6 CR5 CR7 CR9 CR46 CR45 CR44 CR42 CR41 Zhu, Chen, Zhou, Yu, Wang (CR49) 2020; 37 Li, Zhou, Liu, Chen, Zhang (CR55) 2018; 42 Wang, Zhao, Liu, Lu, Jia, Hong, Li, Zhang, Peng, Zhan (CR8) 2018 CR18 CR16 Lv, Cao, Liu, Chen (CR43) 2021; 341 CR14 CR58 CR13 CR12 CR56 CR52 CR51 Deng, Yang, Zhu, Yu, Xu (CR17) 2019; 7 Yan, Wang, Qiu, Wu, Ding, Cai (CR32) 2017; 176 Zhou, Zhao, Yan, Mi, Lu, Luo, Li, Zeng, Cao (CR11) 2020 Alam, Zaidul, Ghafoor, Sahena, Hakim, Rafii, Abir, Bostanudin, Perumal, Khatib (CR40) 2017; 17 Ma, Wang, Gao (CR20) 2016; 82 CR29 Zheng, Zhao, Feng, Wang, Zou, Zheng, Takase, Li, Wu, Yang, Wu (CR22) 2014; 106 CR28 CR27 CR26 Alan, Ahmed (CR1) 2020; 36 CR25 CR24 Chen, Wang, Zhang, Zhang, Ma, Sun, Jin, Zheng, Jiang, Yu, Zhang, Sun (CR57) 2019; 178 CR23 Yang, Wei, Lu, Qiao, Li (CR54) 2021; 350 Wang, Yin, Cao, Li (CR19) 2016; 54 10059_CR6 M Alam (10059_CR40) 2017; 17 10059_CR5 10059_CR7 10059_CR2 10059_CR4 10059_CR3 A Staub (10059_CR21) 1965; 5 J Li (10059_CR15) 2019; 55 X Yang (10059_CR54) 2021; 350 X Fu (10059_CR48) 2020 10059_CR51 10059_CR52 10059_CR14 10059_CR58 10059_CR16 10059_CR12 10059_CR56 10059_CR13 J Chen (10059_CR47) 2019; 215 H Li (10059_CR55) 2018; 42 Q Song (10059_CR33) 2020 M Chen (10059_CR57) 2019; 178 10059_CR41 10059_CR42 10059_CR44 Z Dou (10059_CR34) 2019; 96 10059_CR45 10059_CR46 Y Huo (10059_CR10) 2021; 38 10059_CR29 10059_CR30 S Alan (10059_CR1) 2020; 36 10059_CR31 J Zhu (10059_CR49) 2020; 37 WW Deng (10059_CR17) 2019; 7 10059_CR36 10059_CR37 10059_CR38 10059_CR39 Z Wang (10059_CR8) 2018 10059_CR35 Y Ma (10059_CR20) 2016; 82 10059_CR18 C Wang (10059_CR19) 2016; 54 J Yan (10059_CR32) 2017; 176 Q Lv (10059_CR43) 2021; 341 A Neyrinck (10059_CR50) 2016; 11 W Zhou (10059_CR11) 2020 10059_CR25 10059_CR26 W Zheng (10059_CR22) 2014; 106 10059_CR27 10059_CR28 10059_CR9 10059_CR23 T Thant (10059_CR53) 2019; 17 10059_CR24
References_xml	– ident: CR45 – volume: 82 start-page: 208 issue: 1 year: 2016 end-page: 213 ident: CR20 article-title: Hypoglycemic Activity of Polysaccharides from Sweet Corncob on Streptozotocin-Induced Diabetic Rats publication-title: J. Food Sci. doi: 10.1111/1750-3841.13554 – ident: CR4 – year: 2020 ident: CR11 article-title: Antioxidant and immunomodulatory activities of polysaccharides from bee collected pollen of Chinese wolfberry publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2020.06.244 – ident: CR39 – ident: CR16 – volume: 176 start-page: 11 year: 2017 end-page: 18 ident: CR32 article-title: Purification, structural characterization and bioactivity evaluation of a novel proteoglycan produced by Corbicula fluminea publication-title: Carbohyd. Polym. doi: 10.1016/j.carbpol.2017.08.063 – ident: CR51 – ident: CR12 – ident: CR35 – year: 2018 ident: CR8 article-title: Anti-diabetic activity evaluation of a polysaccharide extracted from Gynostemma pentaphyllum publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2018.12.231 – ident: CR29 – volume: 36 start-page: 407 issue: 3 year: 2020 end-page: 417 ident: CR1 article-title: Cognitive Dysfunction in Older Adults with Type 2 Diabetes: Links, Risks, and Clinical Implications publication-title: Clin. Geriatr. Med. doi: 10.1016/j.cger.2020.04.002 – volume: 42 start-page: 47 year: 2018 end-page: 57 ident: CR55 article-title: Structure characterization of two novel polysaccharides from colocasia esculenta (taro) and a comparative study of their immunomodulatory activities publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2017.12.067 – volume: 17 start-page: 181 issue: 1 year: 2017 ident: CR40 article-title: In vitro antioxidant and α-glucosidase inhibitory activities and comprehensive metabolite profiling of methanol extract and its fractions from Clinacanthus nutans publication-title: BMC Complement. Altern. Med. doi: 10.1186/s12906-017-1684-5 – volume: 11 issue: 8 year: 2016 ident: CR50 article-title: Intestinal sucrase as a novel target contributing to the regulation of glycemia by prebiotics publication-title: PLoS ONE doi: 10.1371/journal.pone.0160488 – ident: CR58 – ident: CR25 – ident: CR42 – ident: CR46 – volume: 178 start-page: 108 year: 2019 end-page: 115 ident: CR57 article-title: New insights into the biological activities of Chrysanthemum morifolium: Natural flavonoids alleviate diabetes by targeting α-glucosidase and the PTP-1B signaling pathway publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2019.05.083 – volume: 5 start-page: 5 year: 1965 end-page: 6 ident: CR21 article-title: Removeal of protein-Sevag method publication-title: Methods in carbohydrate chemistry – ident: CR9 – volume: 7 start-page: 2674 issue: 8 year: 2019 end-page: 2683 ident: CR17 article-title: Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides publication-title: Food Sci. Nutr. doi: 10.1002/fsn3.1123 – ident: CR36 – ident: CR5 – volume: 106 start-page: 335 issue: 12 year: 2014 end-page: 342 ident: CR22 article-title: Purification, characterization and immunomodul atingactivity of a polysaccharide from flowers of publication-title: Carbohyd. Polym. doi: 10.1016/j.carbpol.2014.02.079 – volume: 96 start-page: 568 year: 2019 end-page: 576 ident: CR34 article-title: The effect of ultrasound irradiation on the physicochemical properties and α-glucosidase inhibitory effect of blackberry fruit polysaccharide publication-title: Food Hydrocolloids doi: 10.1016/j.foodhyd.2019.06.002 – ident: CR26 – volume: 37 start-page: 1 issue: 2 year: 2020 end-page: 10 ident: CR49 article-title: Effects of extraction methods on physicochemical properties and hypoglycemic activities of polysaccharides from coarse green tea publication-title: Glycoconj. J. doi: 10.1007/s10719-019-09901-2 – volume: 341 issue: Pt 1 year: 2021 ident: CR43 article-title: Structural characterization, α-amylase and α-glucosidase inhibitory activities of polysaccharides from wheat bran publication-title: Food Chem. doi: 10.1016/j.foodchem.2020.128218 – ident: CR18 – ident: CR14 – ident: CR2 – ident: CR37 – ident: CR30 – year: 2020 ident: CR33 article-title: Chemical structure and inhibition on α-glucosidase of a novel polysaccharide from Hypsizygus marmoreus publication-title: J. Mol. Struct. doi: 10.1016/j.molstruc.2020.128110 – year: 2020 ident: CR48 article-title: Characterization and inhibitory activities on α-amylase and α-glucosidase of the polysaccharide from blue honeysuckle berries publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2020.06.267 – ident: CR6 – ident: CR56 – volume: 38 start-page: 573 issue: 5 year: 2021 end-page: 583 ident: CR10 article-title: Degraded polysaccharides from Porphyra haitanensis: purification, physico-chemical properties, antioxidant and immunomodulatory activities publication-title: Glycoconj. J. doi: 10.1007/S10719-021-10009-9 – ident: CR27 – ident: CR23 – volume: 55 start-page: 1 year: 2019 end-page: 8 ident: CR15 article-title: Transcriptome profiling reveals the anti-diabetic molecular mechanism of Cyclocarya paliurus polysaccharides publication-title: J Func Foods doi: 10.1016/j.jff.2018.12.039 – ident: CR44 – volume: 54 start-page: 3086 issue: 12 year: 2016 end-page: 3092 ident: CR19 article-title: Effects of Maydis stigma polysaccharide on the intestinal microflora in type-2 diabetes publication-title: Pharm. Biol. doi: 10.1080/13880209.2016.1211153 – ident: CR3 – ident: CR38 – ident: CR52 – ident: CR31 – ident: CR13 – volume: 350 issue: 10 year: 2021 ident: CR54 article-title: A neutral polysaccharide with a triple helix structure from ginger: characterization and immunomodulatory activity publication-title: Food Chem. doi: 10.1016/j.foodchem.2021.129261 – volume: 17 start-page: 1339 issue: 1 year: 2019 end-page: 1344 ident: CR53 article-title: Antidiabetes and antioxidant agents from Clausena excavata root as medicinal plant of Myanmar publication-title: Open Chem. doi: 10.1515/chem-2019-0056 – ident: CR7 – volume: 215 start-page: 307 year: 2019 end-page: 315 ident: CR47 article-title: Preliminary characterization, antioxidant and α-glucosidase inhibitory activities of polysaccharides from Mallotus furetianus publication-title: Carbohyd. Polym. doi: 10.1016/j.carbpol.2019.03.099 – ident: CR28 – ident: CR41 – ident: CR24 – ident: 10059_CR51 doi: 10.1080/003655298750026778 – ident: 10059_CR4 doi: 10.1136/bmj.k1795 – volume: 7 start-page: 2674 issue: 8 year: 2019 ident: 10059_CR17 publication-title: Food Sci. Nutr. doi: 10.1002/fsn3.1123 – volume: 17 start-page: 1339 issue: 1 year: 2019 ident: 10059_CR53 publication-title: Open Chem. doi: 10.1515/chem-2019-0056 – ident: 10059_CR41 doi: 10.1016/j.ijbiomac.2020.03.192 – year: 2020 ident: 10059_CR48 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2020.06.267 – ident: 10059_CR46 doi: 10.1016/j.carbpol.2019.115586 – ident: 10059_CR27 doi: 10.1016/j.algal.2020.101883 – volume: 42 start-page: 47 year: 2018 ident: 10059_CR55 publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2017.12.067 – volume: 178 start-page: 108 year: 2019 ident: 10059_CR57 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2019.05.083 – volume: 54 start-page: 3086 issue: 12 year: 2016 ident: 10059_CR19 publication-title: Pharm. Biol. doi: 10.1080/13880209.2016.1211153 – ident: 10059_CR39 doi: 10.1016/j.bgm.2015.08.001 – ident: 10059_CR3 doi: 10.1016/j.diabres.2018.02.023 – ident: 10059_CR2 doi: 10.1016/j.nbd.2019.104608 – ident: 10059_CR38 doi: 10.1016/j.biopha.2020.110182 – ident: 10059_CR16 doi: 10.1016/j.jff.2019.01.037 – volume: 215 start-page: 307 year: 2019 ident: 10059_CR47 publication-title: Carbohyd. Polym. doi: 10.1016/j.carbpol.2019.03.099 – ident: 10059_CR6 doi: 10.1016/j.foodhyd.2020.105824 – volume: 5 start-page: 5 year: 1965 ident: 10059_CR21 publication-title: Methods in carbohydrate chemistry – ident: 10059_CR23 doi: 10.1016/j.carbpol.2017.06.084 – volume: 106 start-page: 335 issue: 12 year: 2014 ident: 10059_CR22 publication-title: Carbohyd. Polym. doi: 10.1016/j.carbpol.2014.02.079 – ident: 10059_CR52 doi: 10.3390/molecules26061677 – ident: 10059_CR44 doi: 10.1016/j.ijbiomac.2018.05.192 – volume: 176 start-page: 11 year: 2017 ident: 10059_CR32 publication-title: Carbohyd. Polym. doi: 10.1016/j.carbpol.2017.08.063 – ident: 10059_CR29 doi: 10.1016/j.carbpol.2017.01.092 – volume: 36 start-page: 407 issue: 3 year: 2020 ident: 10059_CR1 publication-title: Clin. Geriatr. Med. doi: 10.1016/j.cger.2020.04.002 – ident: 10059_CR24 doi: 10.1080/10942912.2017.1297952 – ident: 10059_CR26 doi: 10.3390/molecules22122271 – volume: 96 start-page: 568 year: 2019 ident: 10059_CR34 publication-title: Food Hydrocolloids doi: 10.1016/j.foodhyd.2019.06.002 – year: 2020 ident: 10059_CR11 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2020.06.244 – ident: 10059_CR14 doi: 10.1016/j.fct.2019.110886 – ident: 10059_CR56 doi: 10.1016/j.carbpol.2016.04.106 – ident: 10059_CR12 doi: 10.1016/j.foodres.2018.12.043 – ident: 10059_CR42 doi: 10.1016/j.jff.2016.10.026 – ident: 10059_CR25 doi: 10.1016/j.ijbiomac.2019.11.170 – ident: 10059_CR37 doi: 10.1177/1934578X1801300220 – volume: 341 issue: Pt 1 year: 2021 ident: 10059_CR43 publication-title: Food Chem. doi: 10.1016/j.foodchem.2020.128218 – ident: 10059_CR13 doi: 10.1016/j.ijbiomac.2018.10.200 – volume: 350 issue: 10 year: 2021 ident: 10059_CR54 publication-title: Food Chem. doi: 10.1016/j.foodchem.2021.129261 – ident: 10059_CR36 doi: 10.1002/cbdv.201800070 – ident: 10059_CR35 doi: 10.1080/13880209.2017.1345953 – ident: 10059_CR18 doi: 10.1016/j.ijbiomac.2018.12.251 – ident: 10059_CR58 doi: 10.1016/j.jff.2019.103593 – ident: 10059_CR5 doi: 10.1016/j.carbpol.2020.116659 – volume: 17 start-page: 181 issue: 1 year: 2017 ident: 10059_CR40 publication-title: BMC Complement. Altern. Med. doi: 10.1186/s12906-017-1684-5 – ident: 10059_CR9 doi: 10.1016/j.ijbiomac.2020.02.161 – ident: 10059_CR45 doi: 10.1016/j.ijbiomac.2019.11.170 – ident: 10059_CR7 doi: 10.1016/j.bioorg.2020.103625 – ident: 10059_CR28 doi: 10.1021/acs.jafc.5b05610 – volume: 82 start-page: 208 issue: 1 year: 2016 ident: 10059_CR20 publication-title: J. Food Sci. doi: 10.1111/1750-3841.13554 – volume: 55 start-page: 1 year: 2019 ident: 10059_CR15 publication-title: J Func Foods doi: 10.1016/j.jff.2018.12.039 – volume: 37 start-page: 1 issue: 2 year: 2020 ident: 10059_CR49 publication-title: Glycoconj. J. doi: 10.1007/s10719-019-09901-2 – volume: 11 issue: 8 year: 2016 ident: 10059_CR50 publication-title: PLoS ONE doi: 10.1371/journal.pone.0160488 – ident: 10059_CR30 doi: 10.1016/j.foodhyd.2020.105851 – year: 2020 ident: 10059_CR33 publication-title: J. Mol. Struct. doi: 10.1016/j.molstruc.2020.128110 – volume: 38 start-page: 573 issue: 5 year: 2021 ident: 10059_CR10 publication-title: Glycoconj. J. doi: 10.1007/S10719-021-10009-9 – year: 2018 ident: 10059_CR8 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2018.12.231 – ident: 10059_CR31 doi: 10.1016/j.jff.2019.03.026
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Snippet	In the current study, we extracted a polysaccharide from sweet corncob and evaluated its hypoglycemic function. After collection in water, alcohol...
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SubjectTerms	alpha-Glucosidases - chemistry Animals Biochemistry Biomedical and Life Sciences Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Hypoglycemic Agents - chemistry Life Sciences Original Article Pathology Polysaccharides - chemistry Rats Zea mays
Subtitle	Structural characterization of a novel polysaccharide
Title	Structural characterization of a novel polysaccharide from sweet corncob that inhibits glycosylase in STZ-induced diabetic rats
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