Modulating the antibacterial activity of gold nanoparticles by balancing their monodispersity and aggregation

Aggregation is a key factor influencing the function of nanoparticles. Thioproline-modified gold nanoparticles show potent antibacterial activity, which is compromised by thioproline-mediated particle aggregation. By tuning the balance between the exposure and shielding of thioproline, a maximal ant...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 58; no. 55; pp. 769 - 7693
Main Authors Wang, Le, Zheng, Wenfu, Li, Sixiang, Hou, Qinghong, Jiang, Xingyu
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 07.07.2022
Subjects
Agglomeration
antibacterial properties
chemical communication
exhibitions
Gold
nanogold
Nanoparticles
particles
Shielding
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Summary:Aggregation is a key factor influencing the function of nanoparticles. Thioproline-modified gold nanoparticles show potent antibacterial activity, which is compromised by thioproline-mediated particle aggregation. By tuning the balance between the exposure and shielding of thioproline, a maximal antibacterial property of the gold nanoparticles is achieved. We report a method to balance nanoparticle monodispersity and antibacterial activity. By tuning the balance between the exposure and shielding of active molecules on gold nanoparticles, a maximal antibacterial property is achieved.
Bibliography:https://doi.org/10.1039/d2cc02782h
Electronic supplementary information (ESI) available. See DOI
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SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d2cc02782h