Direct Cobalt-Catalyzed Cross-Coupling Between Aryl and Alkyl Halides

An operationally simple cross-coupling reaction between aryl halides and alkyl halides with high selectivity has been developed. The underlying domino process Utilizes CoCl2/Me-4-DACH as a catalyst system. The methodology exhibits high sustainability as it obviates the need for the pre-formation and...

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Bibliographic Details
Published inSynlett no. 18; pp. 2931 - 2934
Main Authors Czaplik, Waldemar Maximilian, Mayer, Matthias, Jacobi von Wangelin, Axel
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 12.11.2009
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
NICKEL/MAGNESIUM BIMETALLIC COOPERATION
MAGNESIUM
aryl halides
domino reactions
COMPLEXES
cross-coupling
CHLORIDES
cobalt
BROMIDES
GRIGNARD-REAGENTS
ALKENYLATION
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Summary:An operationally simple cross-coupling reaction between aryl halides and alkyl halides with high selectivity has been developed. The underlying domino process Utilizes CoCl2/Me-4-DACH as a catalyst system. The methodology exhibits high sustainability as it obviates the need for the pre-formation and handling of stoichiometric amounts of hazardous Grignard compounds.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0029-1218012