Synthesis of 2-Aminooxazolines and Spiro-2-aminooxazolines by Using a Convenient Two-Step INCO-Mediated Reaction

A two-step reaction sequence yielding 2-aminooxazolines under mild conditions was developed. Both electron-rich and electron-deficient styrenes as well as functionalized primary and secondary amides could be used in the reaction to afford 2-aminooxazolines in reasonable yields.

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Bibliographic Details
Published inSynlett Vol. 24; no. 16; pp. 2140 - 2142
Main Authors Anderson, Corey D., Wilson, Dean M., Mao, Long, Ramirez-Weinhouse, Michele, Long, Daniel D., Crane, Christine M., Jolivet, Catherine, Fanning, Dewey, Molteni, Valentina, Termin, Andreas
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.10.2013
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
library generation
multicomponent reactions
ALKENES
DESIGN
POTENT
heterocycles
MASS-SPECTROMETRY SYSTEM
isocyanate
PURIFICATION
styrene
OXAZOLINES
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Summary:A two-step reaction sequence yielding 2-aminooxazolines under mild conditions was developed. Both electron-rich and electron-deficient styrenes as well as functionalized primary and secondary amides could be used in the reaction to afford 2-aminooxazolines in reasonable yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0033-1339652