Rapid 1,4-Alkynylation of Acyclic Enones Using K[F3BC CR]

Conjugate alkynylation of acyclic enones using sp-hybridised potassium organotrifluoroborates in the presence of BF3 center dot OEt2 is rapidly attained. The simplicity of the processes is Suitable for the preparation of small compound libraries.

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Bibliographic Details
Published inSynlett no. 1; pp. 51 - 54
Main Authors Bertolini, Feituccio, Woodward, Simon
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.01.2009
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CROSS-COUPLING REACTIONS
conjugated alkynylation
potassium organotrifluoroborates
TERMINAL ALKYNES
IONS
COPPER
POTASSIUM
1,4-ADDITION
enones
CONJUGATE ADDITION
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Summary:Conjugate alkynylation of acyclic enones using sp-hybridised potassium organotrifluoroborates in the presence of BF3 center dot OEt2 is rapidly attained. The simplicity of the processes is Suitable for the preparation of small compound libraries.
Bibliography:researchfish
ISSN:0936-5214
DOI:10.1055/s-0028-1087481