Synthesis of 6-Chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile: A Novel, Versatile Intermediate for the Synthesis of Trifluoromethylated Azaindazole Derivatives

A synthesis of 6-chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile, a versatile building block for the synthesis of trifluoromethylated N-heterocycles, is described. The reactions of 6-chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile with 1,2- and 1,3-bisnucleophiles were investigated.

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Bibliographic Details
Published inSynlett Vol. 30; no. 9; pp. 1057 - 1060
Main Authors Channapur, Manjunath B., Hall, Roger G., Kessabi, Jilali, Montgomery, Mark, Shyadligeri, Ashok S.
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.06.2019
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
oxadiazoles
FLUORINE
trifluoromethylation
annulation
pyridinecarbonitriles
pyrazolopyridines
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Summary:A synthesis of 6-chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile, a versatile building block for the synthesis of trifluoromethylated N-heterocycles, is described. The reactions of 6-chloro-5-(trifluoroacetyl)pyridine-3-carbonitrile with 1,2- and 1,3-bisnucleophiles were investigated.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0037-1611815