Base-Promoted Direct Synthesis of Sulfinates from N -Sulfonyl-hydrazones under Metal-Free Conditions

A base-promoted direct synthesis of sulfinates from N-sulfonylhydrazones is described. Various N-sulfonylhydrazones, derived from aldehydes and ketones, are converted into the corresponding sulfinates in moderate to good yields. This protocol possesses many advantages such as readily available and s...

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Bibliographic Details
Published inSynthesis (Stuttgart) Vol. 52; no. 5; pp. 755 - 762
Main Authors Ji, Yuan-Zhao, Wu, Qin-Xi, Li, Hui-Jing, Luo, Dong-Hui, Wu, Yan-Chao
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 03.03.2020
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ASYMMETRIC-SYNTHESIS
ACID
SULFINAMIDES
sulfinates
ONE-POT SYNTHESIS
DIPEA
SULFINYLATION
TOSYLHYDRAZONES VERSATILE REAGENTS
carbonyl compounds
ALCOHOLS
OXIDATIVE REACTION
ESTERS
sulfonylhydrazines
hydrazones
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Summary:A base-promoted direct synthesis of sulfinates from N-sulfonylhydrazones is described. Various N-sulfonylhydrazones, derived from aldehydes and ketones, are converted into the corresponding sulfinates in moderate to good yields. This protocol possesses many advantages such as readily available and stable starting materials, broad substrate scope, and metal-free reaction conditions.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0039-1690754