Clinical and Endoscopic Differences Between Patients With Barrett’s Esophagus With and Without Dysplasia/Adenocarcinoma

• Published in: Curēus (Palo Alto, CA) Vol. 15; no. 10; p. e46323
• Main Authors: Valdovinos-Andraca, Francisco, Bartnicki-Navarrete, Isaac, Bernal-Mendez, Ambrosio R, Rafael Barreto-Zuñiga, Rafael, Romano-Munive, Adriana F, Gamboa-Domínguez, Armando, Elizondo-Rivera, Javier, Briseño-García, Daniel, Tellez-Ávila, Felix I
• Format: Journal Article
• Language: English
• Published: Palo Alto Cureus Inc 01.10.2023; Cureus
• Subjects: Age; Alcohol; Anti-inflammatory agents; Biopsy; Body mass index; Cancer; Endoscopy; Esophageal cancer; Esophagus; Gastroenterology; Gastroesophageal reflux; Gender; Hiatal hernias; Medical prognosis; Multivariate analysis; Oncology; Pathology; Risk factors; Smoking; Ulcers; Variables; Mexico
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.46323

Introduction: Barrett's esophagus (BE) is the main precursor of esophageal adenocarcinoma (EAC). This study aimed to identify the risk factors associated with BE progression to dysplasia or EAC in a Latin population.Methods: The study is a retrospective analysis of a single-center cohort of patients with BE, evaluated from 2002 to 2012.Results: We identified 420 patients with BE; 281 (66.9%) of them were men with a mean age of 57.2 ± 15.3 years. Among all BE patients evaluated, 81 (19.3%) had progression to some degree of dysplasia/EAC. The mean follow-up was 5.6 years. Multivariate analysis showed that age (OR = 1.03), cigarette smoking (OR = 3.05), long-segment BE (OR = 4.81), and a visible lesion on BE (OR = 6.94) were associated with progression to dysplasia/EAC.Conclusion: In Latin patients with BE, age, cigarette smoking, long-segment BE, and the presence of lesions were associated with the presence of dysplasia/EAC.