Pd/Cu-Catalyzed Oxidative C-H Alkenylation of Imidazo[1,2-a]pyridines

A novel direct and regioselective Pd/Cu-catalyzed intermolecular oxidative coupling of imidazo[1,2-a]pyridines with alkenes was successfully developed. The scope and limitations of the reaction were further studied by using various alkenes. This method provides a 'green' route to 3-alkenyl...

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 2; pp. 271 - 276
Main Authors Koubachi, Jamal, Berteina-Raboin, Sabine, Mouaddib, Abderrahim, Guillaumet, Gerald
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 16.01.2009
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PALLADIUM
ACTIVATION
DIOXYGEN
DIRECT ARYLATION
ANNULATION
BOND FORMATION
palladium/copper-catalyzed oxidative coupling
alkenylation
FUNCTIONALIZATION
HETEROCYCLES
CHEMISTRY
INHIBITORS
imidazo[1,2-a]pyridines
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Summary:A novel direct and regioselective Pd/Cu-catalyzed intermolecular oxidative coupling of imidazo[1,2-a]pyridines with alkenes was successfully developed. The scope and limitations of the reaction were further studied by using various alkenes. This method provides a 'green' route to 3-alkenylimidazo[1,2-a]pyridine derivatives in high yields.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0028-1083252