Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides

This work highlights unsymmetrical biaryl compounds via direct nickel-catalyzed reductive coupling of two aryl halides. By tuning the ligand structures, the reaction of two electron-enriched aryl halides also provided the coupling product in good yields, with an excess of 1.4 equivalents of one of t...

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Bibliographic Details
Published inSynlett Vol. 24; no. 5; pp. 619 - 624
Main Authors Qian, Qun, Zang, Zhenhua, Wang, Shulin, Chen, Yang, Lin, Kunhua, Gong, Hegui
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 15.03.2013
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
nickel
UNACTIVATED ALKYL BROMIDES
aryl halides
DIRECT ARYLATION
MECHANISM
FUNCTIONALIZED ARYL
KETONE FORMATION
cross-coupling
BOND FORMATION
biaryl
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Summary:This work highlights unsymmetrical biaryl compounds via direct nickel-catalyzed reductive coupling of two aryl halides. By tuning the ligand structures, the reaction of two electron-enriched aryl halides also provided the coupling product in good yields, with an excess of 1.4 equivalents of one of the halides. The mild reaction conditions display excellent functional-group tolerance and generally gave the coupling products in moderate to good yields. In addition to aryl bromides, activated aryl chlorides are effective.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0032-1318237