Facile and straightforward method leading to substituted 4-amino-1-arylpyrazoles

new method for the synthesis of substituted 4-amino-1-arylpyrazoles is described, starting from beta-enaminones and variously substituted benzenediazonium tetrafluoroborates. The reaction proceeds under mild conditions, is very simple to perform, and is applicable to a relatively wide range of subst...

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 11; pp. 1761 - 1766
Main Authors Simunek, Petr, Svobodova, Marketa, Bertolasi, Valerio, Machacek, Vladimir
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 02.06.2008
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
diazonium salts
NMR
diketones
heterocycles
REACTIVITY
AGENTS
pyrazoles
PYRAZOLE CHEMISTRY
SALTS
enaminones
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Summary:new method for the synthesis of substituted 4-amino-1-arylpyrazoles is described, starting from beta-enaminones and variously substituted benzenediazonium tetrafluoroborates. The reaction proceeds under mild conditions, is very simple to perform, and is applicable to a relatively wide range of substituents, both at the enaminone and diazonium salt starting materials.
ISSN:0039-7881
DOI:10.1055/s-2008-1067042