Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 17; no. 18; pp. 5214 - 5217
Main Authors WARD, Simon E, JOHNSON, Christopher N, LOVELL, Peter J, SCOTT, Claire M, SMITH, Paul W, STEMP, Geoffrey, THEWLIS, Kevin M, VONG, Antonio K, WATSON, Jeannette M
Format Journal Article
LanguageEnglish
Published Oxford Elsevier 15.09.2007
Subjects
Biological and medical sciences
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Serotoninergic system
Rat
Nitrogen heterocycle
Ligand
Lactam
Autoreceptors
5-HT1 Serotonine receptor
Selectivity
Blood brain barrier
Piperidine derivatives
Bicyclic compound
Aromatic compound
Oxygen nitrogen heterocycle
Serotonin
Rodentia
Oral administration
Quinoline derivatives
Depression
Bioavailability
In vitro
In vivo
Vertebrata
Biological fixation
Mammalia
Animal
Affinity
Piperazine derivatives
Pharmacokinetics
5-HT
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ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2007.06.078