Synthesis of Conformationally Locked and C-Linked Analogues of Imidazole-Based Ketene Dithioacetal Fungicides

First examples with the unknown tricyclic 4,8 b -dihydro-3 aH -indeno[1,2- d ][1,3]dithiole ring system have been prepared. Also, imidazoles linked in ring position 5 to a ketene dithioacetal and 1,3-dithiane derivatives with an exocyclic cyano- and imidazole-substituted C-C double bond are complete...

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Bibliographic Details
Published inSynlett Vol. 30; no. 1; pp. 59 - 62
Main Authors Gagnepain, Julien, Jeanmart, Stephane, Bonvalot, Damien, Jacob, Olivier, Lamberth, Clemens
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.01.2019
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Summary:First examples with the unknown tricyclic 4,8 b -dihydro-3 aH -indeno[1,2- d ][1,3]dithiole ring system have been prepared. Also, imidazoles linked in ring position 5 to a ketene dithioacetal and 1,3-dithiane derivatives with an exocyclic cyano- and imidazole-substituted C-C double bond are completely new. All these compounds are either conformationally locked, C-linked or six-ring analogues of the antifungal agent luliconazole. Synthesis and fungicidal activity of these sterol biosynthesis inhibitors are reported.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0037-1610341