New Methodologies for the Synthesis of 3-Acylpyridone Metabolites

A core isoxazolo[4,3-c]pyridin-4-one scaffold is prepared and elaborated at C-3(Me) and C-7 as a masked building block for 3-acylpyridin-2-ones related to the acylpyridone natural products.

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Bibliographic Details
Published inSynlett no. 4; pp. 654 - 658
Main Authors Jones, Raymond C. F., Choudhury, Abdul K., Iley, James N., Loizou, Georgia, Lumley, Christopher, McKee, Vickie
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.03.2010
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
aldol reaction
ACIDS
PYRIDOMACROLIDIN
1,3-DIPOLAR CYCLOADDITION ROUTE
metalation
BEAUVERIA-BASSIANA
cycloaddition
heterocycles
pyridone
BIOSYNTHESIS
TENELLIN
ENTOMOPATHOGENIC FUNGUS
HETEROCYCLIC TRIONES
PYRIDOVERICIN
PAECILOMYCES-MILITARIS
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Summary:A core isoxazolo[4,3-c]pyridin-4-one scaffold is prepared and elaborated at C-3(Me) and C-7 as a masked building block for 3-acylpyridin-2-ones related to the acylpyridone natural products.
ISSN:0936-5214
DOI:10.1055/s-0029-1219341