Streptococcus suis-Associated Meningitis in a Southern Region of Vietnam

• Published in: The American journal of tropical medicine and hygiene Vol. 111; no. 6; pp. 1247 - 1251
• Main Authors: Thanh, Nguyen Huu, Huy, Doan Thanh, Anh, Vo Thi Tram, Anh, Nguyen Ngoc, Uyen, Nguyen Thi Thu, Hanh, Nguyen Ho Hong, Phu, Nguyen Hoan
• Format: Journal Article
• Language: English
• Published: United States Institute of Tropical Medicine 04.12.2024
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Anti-Bacterial Agents - therapeutic use; Antibiotics; Drug resistance; Epidemiology; Female; Humans; Male; Meningitis; Meningitis, Bacterial - drug therapy; Meningitis, Bacterial - epidemiology; Meningitis, Bacterial - microbiology; Middle Aged; Penicillin; Retrospective Studies; Streptococcal Infections - drug therapy; Streptococcal Infections - epidemiology; Streptococcal Infections - microbiology; Streptococcus infections; Streptococcus suis - isolation & purification; Streptococcus suis - pathogenicity; Swine; Vietnam - epidemiology; Vietnam
• ISSN: 0002-9637; 1476-1645; 1476-1645
• DOI: 10.4269/ajtmh.23-0774

Streptococcus suis is the most common and severe cause of meningitis in Vietnam, but the recent data about epidemiological characteristics and sequelae are still inadequate. We performed a retrospective study to describe the epidemiology, clinical characteristics, and outcomes of patients with S. suis -associated meningitis. A retrospective study was carried out by searching records from the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, between January 2016 and January 2020. All data concerning epidemiological, clinical, and subclinical characteristics and treatment results were collected and analyzed. Over the study period, 153 cases were included in this study, with 95 cases occurring in the 2016–2017 period. The median age of all patients was 52 years (range, 29–90 years), and 70.6% of patients were male. Fifty-two patients (34%) were farmers, and the Mekong Delta was the region with the highest number of cases (60.1%). The most frequent manifestation of infection was fever (151/153, 98.7%), followed by hearing loss (64/153, 41.8%), and one patient (0.7%) died. All isolates remained susceptible to ceftriaxone, penicillin, vancomycin, and levofloxacin, whereas 99.2% of isolates were resistant to tetracycline. Occupational exposure to pigs and the consumption of contaminated food have been identified as primary risk factors associated with this zoonosis, and our study found no significant changes in epidemiological factors compared with past data. The Mekong Delta continues to be the most affected region for S. suis meningitis in southern Vietnam, with S. suis serotype 2 remaining the most relevant agent.