Spanlastics a Novel Nanovesicular Carrier: Its Potential Application and Emerging Trends in Therapeutic Delivery

• Published in: AAPS PharmSciTech Vol. 23; no. 4; p. 112
• Main Authors: Ansari, Mohd Danish, Saifi, Zoya, Pandit, Jayamanti, Khan, Iram, Solanki, Pavitra, Sultana, Yasmin, Aqil, Mohd
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 11.04.2022
• Subjects: Administration, Cutaneous; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Drug Carriers - chemistry; Drug Delivery Systems; Excipients - metabolism; Liposomes - chemistry; Particle Size; Pharmacology/Toxicology; Pharmacy; Review Article; Skin - metabolism; Skin Absorption; Surface-Active Agents - chemistry; nanotechnology; edge activator; drug delivery; deformable and elastic vesicle; spanlastic
• ISSN: 1530-9932; 1530-9932
• DOI: 10.1208/s12249-022-02217-9

Nanotechnology-based drug delivery system has played a very crucial role in overpowering the tasks allied with the conventional dosage form. Spanlastics, an elastic nanovesicle with an ability to carry wide range of drug molecules, make it a potential drug delivery carrier. Spanlastics have extended rising curiosity for diverse sort of route of administration. They can squeeze themselves through the skin pore due to elastic and deformable nature which makes them favorable for transdermal delivery. Spanlastics consist of non-ionic surfactant or blend of surfactants. Many researchers proved that spanlastics have been significantly augment therapeutic efficacy, enhanced drug bioavailability, and reduced drug toxicity. This review summarizes various vesicular systems, composition and structure of spanlastics, advantages of spanlastics over other drug delivery systems, and mechanism of drug penetration through skin. It also gives a brief on different types of drug encapsulated in spanlastics vesicles for the treatment of various diseases.