Structure determination, correction, and disproof of marine macrolide natural products by chemical synthesis

Despite significant advances in NMR spectroscopy, structure elucidation of natural products, especially stereochemically complex polyketides with limited availability, is still a challenging task for chemists. Recent examples of structure determination, correction and disproof of structurally comple...

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Bibliographic Details
Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 8; no. 14; pp. 3990 - 4023
Main Author Fuwa, Haruhiko
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 13.07.2021
Subjects
Chemical synthesis
Chemists
Magnetic resonance spectroscopy
Marine chemistry
Natural products
NMR
NMR spectroscopy
Nuclear magnetic resonance
Organic chemistry
Polyketides
Structural analysis
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Summary:Despite significant advances in NMR spectroscopy, structure elucidation of natural products, especially stereochemically complex polyketides with limited availability, is still a challenging task for chemists. Recent examples of structure determination, correction and disproof of structurally complex marine polyketide macrolides by chemical synthesis, namely lobatamide C, reidispongiolide A, callyspongiolide, palmerolide A, muironolide A, iriomoteolide-2a, and chagosensine cases, are summarized in this review, which highlights the scope and limitation of current NMR-based structure analysis and the vital role of chemical synthesis in structure elucidation.
ISSN:2052-4110
2052-4110
DOI:10.1039/d1qo00481f