Unlocking Vitality: A Comprehensive Review of Vitamin D’s Impact on Clinical Outcomes in Critically Ill Children

This comprehensive review explores the multifaceted role of vitamin D (VD) in critically ill children, examining its implications for clinical outcomes. Although this substance has long been known for its function in maintaining bone health, it is now becoming more widely known for its extensive phy...

Full description

Saved in:
Bibliographic Details
Published inCurēus (Palo Alto, CA) Vol. 16; no. 5; p. e60840
Main Authors Vagha, Keta, Taksande, Amar, Lohiya, Sham, Javvaji, Chaitanya Kumar, Vagha, Jayant D, Uke, Punam
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 22.05.2024
Cureus
Subjects
Chronic illnesses
Critical care
Enzymes
Food fortification
Homeostasis
Immunology
Inflammation
Liver
Medical Education
Metabolism
Metabolites
Mineralization
Nutrition
Pediatrics
Physiology
Radiation
Skin
Vegetarianism
Vitamin D
Online AccessGet full text

Cover

More Information
Summary:This comprehensive review explores the multifaceted role of vitamin D (VD) in critically ill children, examining its implications for clinical outcomes. Although this substance has long been known for its function in maintaining bone health, it is now becoming more widely known for its extensive physiological effects, which include immune system and inflammation regulation. Observational research consistently associates VD levels with outcomes like duration of hospitalization, mortality, and illness severity in critically ill pediatric patients. Mechanistically, it exerts anti-inflammatory and endothelial protective effects while modulating the renin-angiotensin system. Increasing VD levels through supplementation presents promise as a therapeutic strategy; however, further research is necessary to elucidate optimal dosage regimens and safety profiles. This review emphasizes the significance of comprehending the intricate relationship between VD and critical illnesses among pediatric populations.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.60840