Streptococcal Toxic Shock Syndrome with Multiple Cerebral Infarctions Caused by Streptococcus dysgalactiae subsp. equisimilis: An Autopsy Case Report

We herein report an autopsy case of streptococcal toxic shock syndrome with disseminated intravascular coagulation and multiple cerebral infarctions induced by Streptococcus dysgalactiae subsp. equisimilis (STSS) in an 84-year-old male. Pathological examination revealed sepsis with hemophagocytosis...

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Bibliographic Details
Published inInternal Medicine p. 3640-24
Main Authors Saito, Sho, Taniuchi, Namiko, Motoda, Norio, Tsunoda, Kanta, Sato, Junpei, Suzuki, Takahiro, Aoyama, Junichi, Nishijima, Nobuhiko, Seike, Masahiro, Saito, Yoshinobu
Format Journal Article
LanguageEnglish
Published The Japanese Society of Internal Medicine 2024
Subjects
autopsy
group G streptococcus
necrotizing fasciitis
Streptococcal toxic shock syndrome
Streptococcus dysgalactiae subsp. equisimilis
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Summary:We herein report an autopsy case of streptococcal toxic shock syndrome with disseminated intravascular coagulation and multiple cerebral infarctions induced by Streptococcus dysgalactiae subsp. equisimilis (STSS) in an 84-year-old male. Pathological examination revealed sepsis with hemophagocytosis in the reticular system and intravascular bacteria in multiple organs, originating from bacterial necrotizing fasciitis of the lower extremities. The brain MRI findings showed a DWI-FLAIR mismatch, whereas the pathology was almost normal, thus supporting a hyperacute phase of cerebral infarction. The findings in this case help to elucidate the pathogenesis of STSS and develop appropriate treatment strategies.
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ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.3640-24