Carcinosarcoma of the uterine cervix arising from Müllerian ducts

• Published in: Obstetrics & gynecology science Vol. 58; no. 3; pp. 251 - 255
• Main Authors: Kim, Myounghwan, Lee, Chulmin, Choi, Hoon, Ko, Ji-Kyung, Kang, Guhyun, Chun, Kyoung-chul
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 01.05.2015; 대한산부인과학회
• Subjects: Case Report; 산부인과학; Breast neoplasms; Cervix uteri; Carcinosarcoma; Müllerian tumor mixed; Müllerian duct
• ISSN: 2287-8572; 2287-8580
• DOI: 10.5468/ogs.2015.58.3.251

Carcinosarcomas of the uterine cervix are extremely rare. Cervical carcinosarcoma can be characterized by having two different origins: the Müllerian ducts and the mesonephric duct remnants. A 53-year-old Korean woman was admitted to the hospital because of pelvic mass detected on computed tomography scan done at private clinic. A Radical hysterectomy with bilateral salpingooophorectomy and pelvic lymphadenectomy was carried out upon a diagnosis of stage IB2 cervical sarcoma. Immunohistochemically, the epithelial component was positive for pancytokeratin and estrogen receptor, but negative for CD 10 and carletinin. The mesenchymal component was positive for vimentin. The histopathologic diagnosis was a carcinosarcoma of the uterine cervix arising from Müllerian ducts. She underwent chemotherapy. She developed systemic recurrence seven months after operation and died of disease. The origin of cervical carcinosarcoma needs to be verified and immunohistochemical studies using mesonephric marker (CD 10, carletinin, and estrogen receptor) is helpful.