Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation

Herein we report the obtaining of 1-(3,4-dihydroquinolin-1(2H)-yl)-2- (4-isobutylphenyl)propan-1-one and its characterization. The newly obtained hybrid and its derivatives (hybrids of ibuprofen with 1,2,3,4-tetrahydroisoquinoline, and piperidine) were screened for their in vitro antioxidant, antitr...

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Bibliographic Details
Published inMolBank Vol. 2022; no. 1; p. M1350
Main Authors Manolov, Stanimir, Ivanov, Iliyan, Bojilov, Dimitar
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.03.2022
Subjects
Albumins
Alzheimer's disease
antioxidant
Antioxidants
Biological activity
Cancer
Denaturation
Enzymes
hybrid molecule
Hydrogen peroxide
Ibuprofen
in silico
in vitro
Inflammation
Malaria
Nonsteroidal anti-inflammatory drugs
Pharmaceutical sciences
Physiology
Piperidine
quinoline
Rheumatoid arthritis
Severe acute respiratory syndrome coronavirus 2
Thin layer chromatography
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Summary:Herein we report the obtaining of 1-(3,4-dihydroquinolin-1(2H)-yl)-2- (4-isobutylphenyl)propan-1-one and its characterization. The newly obtained hybrid and its derivatives (hybrids of ibuprofen with 1,2,3,4-tetrahydroisoquinoline, and piperidine) were screened for their in vitro antioxidant, antitryptic, and inhibition of albumin denaturation activity. The lipophilicity was established using both reversed-phase thin layer chromatography and in silico calculations.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1350