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Blood investigations may reveal elevated alkaline phosphatase, osteocalcin, collagen metabolites, and urinary hydroxyproline with normal levels of serum calcium, parathyroid hormone, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D. Individuals with extensive polyostotic FD may have hypophosphatemia...

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Bibliographic Details
Published inEndocrine practice Vol. 24; no. 5; p. 501
Main Authors Binu, Aditya John, Cherian, Kripa Elizabeth, Kapoor, Nitin, Hephzibah, Julie, Paul, Thomas Vizhalil
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 01.05.2018
Subjects
Adult
Alkaline Phosphatase - blood
Bisphosphonates
Bone and Bones - diagnostic imaging
Female
Femur - diagnostic imaging
Fibrous Dysplasia, Polyostotic - blood
Fibrous Dysplasia, Polyostotic - diagnostic imaging
Hip joint
Humans
Pain
Phosphatase
Radiography
Radionuclide Imaging
Radiopharmaceuticals
Technetium Tc 99m Medronate
Vitamin D
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Summary:Blood investigations may reveal elevated alkaline phosphatase, osteocalcin, collagen metabolites, and urinary hydroxyproline with normal levels of serum calcium, parathyroid hormone, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D. Individuals with extensive polyostotic FD may have hypophosphatemia, hyperphosphaturia, and osteomalacia (2). Conventional 3-phase bone scans in FD show hyperemia, increased blood pool, and tracer uptake in the delayed cortical phase secondary to the high bone turnover associated with immature woven bone. Adult patients with FD can be treated with parenteral or oral bisphosphonates, which will significantly reduce pain and bone turnover and improve the quality of life in majority of subjects.
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ISSN:1530-891X
1934-2403
DOI:10.4158/EP-2017-0167