FACILE SYNTHESIS OF SPIROOXINDOLES VIA AN ENANTIOSELECTIVE ORGANOCATALYZED SEQUENTIAL REACTION OF OXINDOLES WITH YNONE
The reaction of oxindole la with phenylprop-2-yn-l-one (2a) was promoted by the chiral multifunctional phosphine catalyst 4a derived from (S)-valine, giving spirooxindole 3a in good yield and high enantioselectivity. The obtained spirooxindole forms a common scaffold of a vast number of natural prod...
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Published in | Heterocycles Vol. 95; no. 2; pp. 761 - 767 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
2017
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Subjects | |
Online Access | Get more information |
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Summary: | The reaction of oxindole la with phenylprop-2-yn-l-one (2a) was promoted by the chiral multifunctional phosphine catalyst 4a derived from (S)-valine, giving spirooxindole 3a in good yield and high enantioselectivity. The obtained spirooxindole forms a common scaffold of a vast number of natural products exhibiting various biological activities. |
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ISSN: | 0385-5414 1881-0942 |
DOI: | 10.3987/COM-16-S(S)86 |