A New Chromene Derivative and a New Polyalcohol Isolated From the Fungus Xylaria sp. 111A Associated With Garcinia polyantha Leaves

From the crude extract of the plant-associated fungus Xylaria sp. collected in Cameroon, a new 2H-chromene derivative, hexacycloxylariolone (1), and a new polyalcohol, xylatriol (2), were isolated, in addition to 3 known compounds, 2,3-furandiol (3), 1,8-dimethoxynaphthalene (4), and 1-palmitoyl-rac...

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Bibliographic Details
Published inNatural product communications Vol. 16; no. 1
Main Authors Tegha, Hycienth Fung, Jouda, Jean-Bosco, Dzoyem, Jean Paul, Sema, Denis Kehdinga, Leutcha, Bosco Peron, Allémann, Eric, Delie, Florence, Shiono, Yoshihito, Sewald, Norbert, Lannang, Alain Meli
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2021
Subjects
Garcinia polyantha
Xylaria
antiproliferative activity
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Summary:From the crude extract of the plant-associated fungus Xylaria sp. collected in Cameroon, a new 2H-chromene derivative, hexacycloxylariolone (1), and a new polyalcohol, xylatriol (2), were isolated, in addition to 3 known compounds, 2,3-furandiol (3), 1,8-dimethoxynaphthalene (4), and 1-palmitoyl-rac-glycerol (5). Their chemical structures were established on the basis of the interpretation of spectroscopic data. Hexacycloxylariolone (1), 1,8-dimethoxynaphthalene (4), and 1-palmitoyl-rac-glycerol (5) showed antiproliferative activity by inhibiting the growth of Raw 264.7 and THP-1 cancer cell lines.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X20987334