A NEW DERIVATIVE OF GALANTHAMINE: METHYLENE INSERTION INTO THE AROMATIC RING IN PLACE OF CYCLOPROPANATION

In the course of the reaction between galanthamine and diazomethane in the presence of a catalyst, such as palladium(II) acetate or copper(I) bromide, methylene insertion into the aromatic ring was observed instead of the expected cyclopropanation of the carbon-carbon double bond.

Saved in:
Bibliographic Details
Published inHeterocycles Vol. 84; no. 2; pp. 1171 - 1178
Main Authors Keglevich, Peter, Kovacs, Peter, Hazai, Laszlo, Santa, Zsuzsanna, Dubrovay, Zsofia, Hada, Viktor, Szantay, Csaba, Kalaus, Gyoergy
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.01.2012
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Cyclopropanation
ORGANIC-SYNTHESIS
ASYMMETRIC-SYNTHESIS
(-)-GALANTHAMINE
REAGENTS
Methylene Insertion
Cycloheptatriene Ring
(+/-)-GALANTHAMINE
Galanthamine
TRIMETHYLSILYLDIAZOMETHANE
Diazomethane
ALKALOIDS
Online AccessGet more information

Cover

More Information
Summary:In the course of the reaction between galanthamine and diazomethane in the presence of a catalyst, such as palladium(II) acetate or copper(I) bromide, methylene insertion into the aromatic ring was observed instead of the expected cyclopropanation of the carbon-carbon double bond.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-11-S(P)98