Liver Elastography as a Predictor of Esophageal Varices in Patients With Cirrhosis

• Published in: Curēus (Palo Alto, CA) Vol. 13; no. 10; p. e18593
• Main Authors: Danish, Muhammad, Ismail, Hina, Tulsi, Rani, Mehmood, Nasir, Laeeq, Syed Muddasir, Hassan Luck, Nasir
• Format: Journal Article
• Language: English
• Published: Palo Alto Cureus Inc 08.10.2021; Cureus
• Subjects: Accuracy; Ascites; Body mass index; Endoscopy; Esophagus; Gastroenterology; Gender; General Surgery; Hepatitis; Hepatitis B; Hepatitis C; Hepatitis delta virus; Internal Medicine; Laboratories; Liver cirrhosis; Liver diseases; Patients; Karachi Pakistan; Pakistan
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.18593

IntroductionLiver cirrhosis is an advanced consequence of a long-standing liver disease that can lead to portal hypertension which subsequently can manifest as life-threatening variceal bleeding. The present study aimed to determine liver stiffness by shear wave elastography (SWE) to predict esophageal varices (EV) in patients with chronic liver diseases.MethodologyA prospective observational study was performed at the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi between November 2020 and July 2021. Individuals aged between 18 and 50 years, irrespective of gender, with diagnosed chronic liver disease >6 months were eligible to partake in the study. Patients with concomitant renal failure, severe ascites, severe life-threatening co-morbidities including congestive heart failure NYHA-III and IV, acute asthmatic attack, and recent myocardial infarction (MI) were excluded from the study. SWE was determined in all patients to measure liver stiffness. Esophagogastroduodenoscopy (EGD) was performed to visualize the esophageal varices. All findings were recorded. A 2 × 2 table was applied to determine the sensitivity, specificity, positive, and diagnostic accuracy for SWE by taking endoscopy as the definitive test.ResultsA total of 204 patients were included in the study. Mean age of 40.37 ± 15.20 years was observed. The mean liver size of patients was 12.38 ± 2.06 cm and the mean liver stiffness of patients was 19.97 ± 8.6. The sensitivity and specificity of liver elastography were 44.90% and 51.90%, respectively. Furthermore, the positive and negative predictive values were 53.00% and 99.39%, respectively. The diagnostic accuracy of the test was 51.86%.ConclusionEven though the diagnostic gold standard for the detection of varices is EGD, liver elastography provides a less invasive procedure to assess for varices in patients with cirrhotic liver disease. The present study concluded that liver elastography is a non-invasive and indirect valuable tool to predict the presence of esophageal varices with sensitivity and specificity of 44.90% and 51.90%, respectively.