Oxidative status and its relation with insulin resistance in young non-obese women with polycystic ovary syndrome

• Published in: Journal of endocrinological investigation Vol. 35; no. 3; pp. 317 - 321
• Main Authors: Kurdoglu, Z., Ozkol, H., Tuluce, Y., Koyuncu, I.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2012
• Subjects: Adult; Antioxidants - metabolism; beta Carotene - blood; Blood Glucose - metabolism; Body Weight - physiology; Catalase - blood; Endocrinology; Female; Glucose Tolerance Test; Glutathione - blood; Glutathione Transferase - blood; Homeostasis - physiology; Hormones - blood; Humans; Hyperinsulinism - metabolism; Insulin Resistance - physiology; Malondialdehyde - blood; Medicine; Medicine & Public Health; Metabolic Diseases; Original Articles; Oxidative Stress - physiology; Polycystic Ovary Syndrome - metabolism; Protein Carbonylation - physiology; Vitamins - blood; Young Adult; Antioxidant status; PCOS; insulin resistance; oxidative stress
• ISSN: 0391-4097; 1720-8386
• DOI: 10.3275/7682

Background: Oxidative stress may play a role in the pathophysiology of polycystic ovary syndrome (PCOS). Insulin resistance (IR) also can be found in young non-obese women with PCOS. Hyperglycemia may increase reactive oxygen species production and decrease antioxidant levels. Aim: To investigate oxidative status and its relation with IR in young non-obese patients with PCOS. Material/subjects and methods: Thirty-one patients with hyperinsulinemic (no.=13) and normoinsulinemic (no.=18) PCOS and 29 healthy controls were included in this study. Serum levels of glucose, insulin, gonadotropins, total testosterone, DHEAS, SHBG, 2-h plasma glucose on oral glucose tolerance test, malondialdehyde (MDA), protein carbonyl (PC), reduced glutathione (GSH), β carotene, vitamin A, C, E and the enzyme activities of catalase and glutathione S-transferase (GST), IR [by homeostasis model assessment (HOMA)-IR], and β cell function [by HOMA-B] were assessed. Results: Serum glucose, insulin, total testosterone, DHEAS, HOMA-IR levels, and LH/FSH ratios were higher in young non-obese women with PCOS. Serum MDA and PC levels were also higher but GSH, vitamin C and E levels, and GST enzyme activity were lower in these women than in healthy controls, independently of the status of IR ( p <0.05). Conclusions: Oxidative stress characterized by increased oxidants and decreased antioxidant levels which are independent of IR may be involved in the pathogenesis of PCOS in young non-obese women.