Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland: A Rare Case

Cancer is a major cause of morbidity and mortality worldwide, with squamous cell carcinoma (SCC) being the most common type. Even though SCC is the major type of cancer found in the head and neck region, the salivary glands contribute to about 1/20 cases, of which 1/10 are said to be carcinoma ex pl...

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Published inCurēus (Palo Alto, CA) Vol. 14; no. 5; p. e25357
Main Authors Umar, Zaryab, Ilyas, Usman, Alshamam, Mohsen S, Foster, Allison, Bhangal, Rubal, Ahmed, Nazaakat, Idrees, Zarwa
Format Journal Article
LanguageEnglish
Published Palo Alto Springer Nature B.V 26.05.2022
Cureus
Subjects
Adrenal glands
Antigens
Biomarkers
Biopsy
Brain cancer
Cancer
Case reports
Cellular biology
Cytokeratin
Exocrine glands
Internal Medicine
Liver
Lungs
Lymphatic system
Medical imaging
Metastasis
Oncology
Oral cancer
Pleural effusion
Pulmonology
Radiation therapy
Squamous cell carcinoma
Tomography
Tumors
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Summary:Cancer is a major cause of morbidity and mortality worldwide, with squamous cell carcinoma (SCC) being the most common type. Even though SCC is the major type of cancer found in the head and neck region, the salivary glands contribute to about 1/20 cases, of which 1/10 are said to be carcinoma ex pleomorphic adenoma (CXPA) type, and the parotid gland is found to be the most common origin of such cases. Although it usually arises later in life, it can grow rapidly, with local symptoms being late findings, if any. Even though fine needle aspiration cytology has low sensitivity for diagnosing such cancer, multiple/repeated biopsies can increase the yield and the accuracy of the test. Surgical resection is the main choice for treatment with postoperative radiation for select cases. Our case presented with CXPA with distant metastasis to multiple sites.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.25357