Amipaque: a new contrast medium in coronary angiography. Report of a double-blind study in man

Isopaque Coronar and Amipaque (metrizamide) were evaluated in a comparative double-blind study of 30 patients with heart disease undergoing selective coronary angiography. Amipaque alone was also used for 9 additional patients undergoing left ventriculography, aortic root injection, and selective co...

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Bibliographic Details
Published inRadiology Vol. 125; no. 2; p. 317
Main Authors Enge, I, Nitter-Hauge, S, Andrew, E, Levorstad, K
Format Journal Article
LanguageEnglish
Published United States 01.11.1977
Subjects
Adult
Aged
Angiography
Clinical Trials as Topic
Coronary Angiography
Double-Blind Method
Female
Heart Rate - drug effects
Humans
Iodobenzoates - pharmacology
Male
Metrizamide - pharmacology
Metrizoic Acid - pharmacology
Middle Aged
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Summary:Isopaque Coronar and Amipaque (metrizamide) were evaluated in a comparative double-blind study of 30 patients with heart disease undergoing selective coronary angiography. Amipaque alone was also used for 9 additional patients undergoing left ventriculography, aortic root injection, and selective coronary angiography. Amipaque resulted in significantly less of a decrease in diastolic pressure and heart rate, reduced chest pain and heat sensation, and longer coronary contrast transit time. Electrorocardiographic parameters and image quality were equivalent with the 2 agents. No pathological changes were noted in the 9 patients undergoing complete angiocardiographic study.
ISSN:0033-8419
DOI:10.1148/125.2.317