Physiology of diastolic function and transmitral pressure-flow relations

The study of diastolic function, in particular, the creative application of noninvasive modalities, such as echocardiography and MR imaging, requires an understanding and appreciation of the basic physiology of left ventricular filling dynamics. The physics and physiology of diastolic function and d...

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Bibliographic Details
Published inCardiology clinics Vol. 18; no. 3; p. 411
Main Authors Yellin, E L, Meisner, J S
Format Journal Article
LanguageEnglish
Published Netherlands 01.08.2000
Subjects
Animals
Blood Flow Velocity - physiology
Blood Pressure - physiology
Computer Simulation
Diastole - physiology
Heart Atria - physiopathology
Heart Failure - physiopathology
Heart Ventricles - physiopathology
Humans
Mitral Valve - physiopathology
Models, Cardiovascular
Myocardial Contraction - physiology
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Summary:The study of diastolic function, in particular, the creative application of noninvasive modalities, such as echocardiography and MR imaging, requires an understanding and appreciation of the basic physiology of left ventricular filling dynamics. The physics and physiology of diastolic function and dysfunction is examined by relating the phasic patterns of transmitral flow to the properties of the cardiac chambers. Particular attention is paid to the equations governing the transmitral pressure-flow relations and the active and passive chamber properties that determine the flow patterns: Active relaxation, passive compliance, viscoelasticity, and elastic deformation. The physiologic role of diastolic suction is discussed within this context.
ISSN:0733-8651
DOI:10.1016/S0733-8651(05)70153-3