Weill-Marchesani syndrome with bilateral angle-closure glaucoma

• Published in: Journal of pediatric ophthalmology and strabismus Vol. 22; no. 4; pp. 129 - 132
• Main Authors: WRIGHT, K. W, CHROUSOS, A
• Format: Journal Article
• Language: English
• Published: Thorofare, NJ Slack 01.07.1985; SLACK INCORPORATED
• Subjects: Abnormalities, Multiple - complications; Abnormalities, Multiple - drug therapy; Biological and medical sciences; Body Constitution; Child; Eye Diseases - complications; Fingers - abnormalities; Glaucoma; Glaucoma - drug therapy; Glaucoma - etiology; Glaucoma - surgery; Glaucoma and intraocular pressure; Humans; Joints - abnormalities; Male; Medical sciences; Metacarpus - abnormalities; Ophthalmology; Pilocarpine - adverse effects; Pilocarpine - therapeutic use; Skull - abnormalities; Syndrome; Human; Glaucoma; Eye disease; Diseases of the osteoarticular system; Bilateral; Marchesani dwarfism; Cycloplegia; Child; Angle closure glaucoma
• ISSN: 0191-3913; 1938-2405
• DOI: 10.3928/0191-3913-19850701-04

To our knowledge this is the first reported case of cyclopentolate induced bilateral acute angle-closure glaucoma associated with the Weill-Marchesani syndrome without lens subluxation. The diagnosis of Weill-Marchesani syndrome was not initially suspected, and Pilocarpine was used in an attempt to break the acute attack. Treatment with Pilocarpine-induced myosis only worsened the glaucoma by causing a severe pupillary block. This case is important because it demonstrates that mid-dilatation and cycloplegia can induce acute glaucoma in patients with the Weill-Marchesani syndrome and points out the importance for considering the diagnosis of Weill-Marchesani syndrome in any case of acute glaucoma in childhood.