Heptacyclosordarianone, a New Polyketide From Sordaria sp., an Endophytic Fungus From Garcinia polyantha

One new polyketide derivative, heptacyclosordarianone (1), together with 2 known compounds, heptacyclosordariolone (2) and sordariol (3), were isolated from an extract of Sordaria sp. AM-71, an endophytic fungus inhabiting Garcinia polyantha. The structures of these compounds were elucidated based o...

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Published inNatural product communications Vol. 15; no. 12
Main Authors Tsague Tankeu, Virginie Flaure, Sema, Denis Kehdinga, Jouda, Jean-Bosco, Tatsimo, Simplice Joel N., Ntonga, Patrick Akono, Wansi, Jean Duplex, Fogue, Simeon Kouam, Loura, Benoît, Shiono, Yoshihito, Sewald, Norbert, Lannang, Alain Meli
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.12.2020
Subjects
Sordaria sp
antimicrobial activity
Garcinia
polyketide
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Summary:One new polyketide derivative, heptacyclosordarianone (1), together with 2 known compounds, heptacyclosordariolone (2) and sordariol (3), were isolated from an extract of Sordaria sp. AM-71, an endophytic fungus inhabiting Garcinia polyantha. The structures of these compounds were elucidated based on intensive nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry and by comparison with literature data. All compounds were assayed for their antimicrobial and cytotoxic properties. Only compound 2 showed antimicrobial activities against Bacillus subtilis DSMZ 704, Pseudomonas agarici DSMZ 11810, and Micrococcus luteus DSMZ 1605 with minimum inhibitory concentration values of 9.3, 15.5, and 16.9 µg/mL respectively. None of the isolated compounds showed a significant cytotoxic property.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X20977622