Extensive brainstem lesions in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A case report

• Published in: Radiology case reports Vol. 19; no. 12; pp. 5589 - 5594
• Main Authors: Kojita, Yasuyuki, Okada, Nonoka, Hirakawa, Mayumi, Fujii, Kanako, Satou, Takao, Ishii, Kazunari
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2024; Elsevier
• Subjects: 18F-fluorodeoxyglucose positron emission tomography; Case Report; Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids; Computed tomography; Lymphoma; Magnetic resonance imaging; Myelin oligodendrocyte glycoprotein antibody-associated disease; CLIPPERS; 18F-fluorodeoxyglucose positron emission tomography; 18F-FDG PET; Myelin oligodendrocyte glycoprotein antibody-associated disease; MOG; Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids; H&E; CNS; MOGAD; Lymphoma; IVMP; Computed tomography; Magnetic resonance imaging; ADEM; CSF
• ISSN: 1930-0433; 1930-0433
• DOI: 10.1016/j.radcr.2024.08.032

Myelin oligodendrocyte glycoprotein antibody-associated disease is a group of central nervous system demyelinating disorders caused by autoantibodies. While myelin oligodendrocyte glycoprotein antibody-associated disease typically presents as optic neuritis and myelitis in adults, this case report details a patient with brainstem lesions. A 45-year-old male presented with episodes of vertigo, nystagmus, and diplopia in left lateral gaze, which had persisted for 2 months, accompanied by headache. Computed tomography showed hyperdensity extending from the left side of the pons to the middle cerebellar peduncle. Magnetic resonance imaging revealed lesions exhibiting heterogeneous diffusion restriction, with enhancement that included granular and linear patterns. 18F-fluorodeoxyglucose positron emission tomography demonstrated increased uptake in these lesions. Following further evaluation, myelin oligodendrocyte glycoprotein antibody-associated disease was diagnosed. Treatment with high-dose corticosteroids initially alleviated symptoms, but symptoms flared upon reduction of the steroids. This case underscores the importance of considering myelin oligodendrocyte glycoprotein antibody-associated disease in the differential diagnosis of brainstem lesions and discusses distinguishing imaging features from similar conditions.