Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19

Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all an...

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Published inJournal of medical microbiology Vol. 70; no. 8
Main Authors Mc Gann, Patrick, Geringer, Matthew R., Hall, Lindsey R., Lebreton, Francois, Markelz, Elizabeth, Kwak, Yoon I., Johnson, Sheila, Ong, Ana C., Powell, Aubrey, Tekle, Tsigereda, Bergman, Yehudit, Simner, Patricia J., Bennett, Jason W., Cybulski, Robert J., White, Brian K.
Format Journal Article
LanguageEnglish
Published Microbiology Society 27.08.2021
Subjects
Antimicrobial Resistance
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Summary:Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase bla NDM-1 , the extended-spectrum β-lactamase bla PER-1 , and the rare 16S methyltransferase rmtB2 .
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Genbank Accession: The genome sequence of P. rettgeri MRSN 845308 has been deposited at NCBI with Accession number JAEEFV000000000.
ISSN:0022-2615
1473-5644
DOI:10.1099/jmm.0.001406