Parotid gland MALT lymphoma with amyloid deposition, challenges in preoperative diagnosis: A case report

Mucosa-associated lymphoid tissue (MALT) lymphoma commonly arises from chronic inflammation or autoimmune diseases, such as Sjögren syndrome (SjS). Although rare, amyloid deposition in MALT lymphoma has been reported. We present a rare case of parotid gland MALT lymphoma in a 49-year-old woman, in w...

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Published inRadiology case reports Vol. 19; no. 12; pp. 6141 - 6146
Main Authors Watanabe, Yuriko, Fujii, Hiroyuki, Yamamoto, Saki, Masuoka, Sota, Kobayashi, Ryoma, Fujii, Nana, Nakamata, Akihiro, Kanazawa, Takeharu, Matsuki, Mitsuru, Mori, Harushi
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.12.2024
Elsevier
Subjects
Amyloidosis
Case Report
MALT lymphoma
MRI
Parotid gland
Sjögren syndrome
ADC
FDG-PET
Parotid gland
MRI
SUVmax
T1WI
Sjögren syndrome
DFS
CT
RBC
MALT lymphoma
T2WI
DWI
WBC
Amyloidosis
FLC
SjS
HE
MALT
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Summary:Mucosa-associated lymphoid tissue (MALT) lymphoma commonly arises from chronic inflammation or autoimmune diseases, such as Sjögren syndrome (SjS). Although rare, amyloid deposition in MALT lymphoma has been reported. We present a rare case of parotid gland MALT lymphoma in a 49-year-old woman, in whom preoperative diagnosis was challenging due to atypical imaging findings resulting from amyloid deposits. MRI showed T2-hypointense and T1-iso- to slightly hyperintense masses in the left parotid gland and right sublingual gland, with predominant marginal contrast enhancement and no significant diffusion restriction. Additionally, atrophy and fatty replacement of the parenchyma were noted in bilateral parotid glands, suggesting SjS. Left superficial parotidectomy was performed and pathological findings confirmed MALT lymphoma with extensive amyloid deposition. Histopathological findings of the resected parotid gland parenchyma also suggested SjS. MALT lymphoma should be considered in the differential diagnosis of multiple salivary gland masses in patients with suspected SjS. If MRI reveals atypical imaging findings for malignant lymphoma, particularly T2-hypointensity with no significant diffusion restriction, the possibility of amyloid deposition in MALT lymphoma should be considered.
Bibliography:ObjectType-Case Study-2
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ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2024.09.083