Early renal failure as a cardiovascular disease:Focus on lipoprotein(a) and prothrombotic state

Patients with renal failure are at increased risk of cardiovascular events even at the earliest stages of disease.In addition to many classic cardiovascular risk factors,many conditions that are commonly identified as emerging risk factors might contribute to occurrence of cardiovascular disease.Cha...

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Published inWorld journal of nephrology Vol. 4; no. 3; pp. 374 - 378
Main Authors Catena, Cristiana, Colussi, GianLuca, Nait, Francesca, Pezzutto, Francesca, Martinis, Flavia, Sechi, Leonardo A
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 06.07.2015
Subjects
Minireviews
Cardiovascular disease
Lipoprotein(a)
Prothrombotic state
Early renal failure
Risk factors
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Summary:Patients with renal failure are at increased risk of cardiovascular events even at the earliest stages of disease.In addition to many classic cardiovascular risk factors,many conditions that are commonly identified as emerging risk factors might contribute to occurrence of cardiovascular disease.Changes in circulating levels of many of these emerging risk factors have been demonstrated in patients with early stages of renal failure caused by different types of renal disease and have been associated with detection of cardiovascular complications.However,for most of these factors evidence of benefits of correction on cardiovascular outcome is missing.In this article,we comment on the role of lipoprotein(a) and prothrombotic factors as potential contributors to cardiovascular events in patients with early renal failure.
Bibliography:Cristiana Catena;Gian Luca Colussi;Francesca Nait;Francesca Pezzutto;Flavia Martinis;Leonardo A Sechi;Clinica Medica,Department of Experimental and Clinical Medical Sciences,University of Udine
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Correspondence to: Leonardo A Sechi, MD, Clinica Medica, Department of Experimental and Clinical Medical Sciences, University of Udine, Via delle Scienze, 208, 33100 Udine, Italy. sechi@uniud.it
Telephone: +39-432-559804 Fax: +39-432-559890
Author contributions: Catena C and Sechi LA planned the article outline, retrived articles from the literature, wrote the manuscript; Colussi G, Nait F, Pezzutto F and Marinis F retrieved articles from the literature and critically reviewed the manuscript.
ISSN:2220-6124
2220-6124
DOI:10.5527/wjn.v4.i3.374