Impact of automated pop-up alerts on simultaneous prescriptions of antimicrobial agents and metal cations

• Published in: Journal of pharmaceutical health care and sciences Vol. 10; no. 1; pp. 59 - 6
• Main Authors: Matsumoto, Takanori, Matsumoto, Taichi, Tsutsumi, Chiyo, Hadano, Yoshiro
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.09.2024; BMC
• Subjects: Antimicrobial agents; Automated pop-up alerts; Bacteria; Chelation; Drug resistance; Drugstores; Health aspects; Infection; Metal cations; Pharmacists; Pharmacy; Prescription writing; Tetracycline; Tetracyclines; Chelation; Automated pop-up alerts; Antimicrobial agents; Metal cations
• ISSN: 2055-0294; 2055-0294
• DOI: 10.1186/s40780-024-00377-3

Antimicrobial agents (AMAs) are essential for treating infections. A part of AMAs chelate with metal cations (MCs), reducing their blood concentrations. That drug-drug interaction could lead to a reduction of therapeutic efficacy and the emergence of drug-resistant bacteria. However, prescriptions ordering concomitant intake (co-intake) of AMAs and MCs are frequently seen in clinical settings. A method for preventing such prescriptions is urgently needed. We implemented pop-up alerts in the hospital's ordering and pharmacy dispensation support system to notify the prescriptions ordering co-intake of AMAs and MCs for physicians and pharmacists, respectively. To assess the effectiveness of the pop-up alerts, we investigated the number of prescriptions ordering co-intake of AMAs and MCs and the number of pharmacist inquiries to prevent co-intake of AMAs and MCs before and after the implementation of pop-up alerts. Before the implementation of pop-up alerts, 84.5% of prescriptions containing AMA and MCs ordered co-intake of AMAs and MCs. Implementing pop-up alerts time-dependently reduced the proportion of prescriptions ordering co-intake of AMAs and MCs to 43.8% and 29.5% one year and two years later, respectively. The reduction of tetracycline-containing prescriptions was mainly significant. Before the implementation of pop-up alerts, the proportion of prescriptions in which pharmacists prevented co-intake of AMAs and MCs was 3.4%. Implementing pop-up alerts time-dependently increased proportions of such prescriptions to 20.9% and 28.2% one year and two years later. Implementing pop-up alerts reduced prescriptions ordering co-intake of AMAs and MCs and accelerated pharmacists to prevent co-intake of AMAs and MCs. The implementation of dual pop-up alerts in the hospital's ordering and pharmacy dispensation support system could help prevent co-intake of AMAs and MCs.